Partial agonistic effect of yokukansan on human recombinant serotonin 1A receptors expressed in the membranes of Chinese hamster ovary cells

K Terawaki, Y Ikarashi, K Sekiguchi, Y Nakai… - Journal of …, 2010 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Yokukansan (YKS) is a traditional Japanese
medicine consisted of seven medicinal herbs and has been used for treatment of neurosis …

Effects of Geissoschizine Methyl Ether, an Indole Alkaloid in Uncaria Hook, a Constituent of Yokukansan, on Human Recombinant Serotonin7 Receptor

T Ueki, A Nishi, S Imamura, H Kanno… - Cellular and molecular …, 2013 - Springer
Abstract Effects of seven alkaloids, geissoschizine methyl ether (GM), hirsutine, hirsuteine,
rhynchophylline, isorhynchophylline, corynoxeine and isocorynoxeine, in Uncaria hook, a …

Geissoschizine methyl ether, an alkaloid in Uncaria hook, is a potent serotonin1A receptor agonist and candidate for amelioration of aggressiveness and sociality by …

A Nishi, T Yamaguchi, K Sekiguchi, S Imamura… - Neuroscience, 2012 - Elsevier
Yokukansan (YKS), a traditional Japanese medicine, is composed of seven kinds of dried
herbs. It is widely prescribed in clinical situation for treating psychiatric disorders such as …

Anxiolytic effects of yokukansan, a traditional Japanese medicine, via serotonin 5-HT1A receptors on anxiety-related behaviors in rats experienced aversive stress

T Yamaguchi, A Tsujimatsu, H Kumamoto… - Journal of …, 2012 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Yokukansan, a traditional Japanese medicine
(Kampo), has been reported in the treatment of behavioral and psychological symptoms of …

Brain region-specific reduction in c-Fos expression associated with an anxiolytic effect of yokukansan in rats

H Shoji, K Mizoguchi - Journal of ethnopharmacology, 2013 - Elsevier
Ethnopharmacological relevance A traditional Japanese (Kampo) medicine, yokukansan,
has long been used to treat neurosis, insomnia, and night crying and irritability in children …

[HTML][HTML] Pharmacokinetics of active components of yokukansan, a traditional Japanese herbal medicine after a single oral administration to healthy Japanese …

H Kitagawa, M Munekage, K Ichikawa, I Fukudome… - PLoS …, 2015 - journals.plos.org
Context Yokukansan (YKS) is a traditional Japanese herbal medicine called kampo
medicine in Japan. Its extract comprises seven crude drugs: Atractylodis lanceae rhizoma …

[HTML][HTML] Cellular pharmacological effects of the traditional Japanese kampo medicine yokukansan on brain cells

K Mizoguchi, Y Ikarashi - Frontiers in Pharmacology, 2017 - frontiersin.org
Yokukansan (YKS) is a traditional Japanese Kampo medicine currently used for the
treatment of the behavioral psychological symptoms associated with dementia (BPSD) …

[HTML][HTML] Identification of Glycyrrhiza as the rikkunshito constituent with the highest antagonistic potential on heterologously expressed 5-HT3A receptors due to the …

R Herbrechter, PM Ziemba, KM Hoffmann… - Frontiers in …, 2015 - frontiersin.org
The traditional Japanese phytomedicine rikkunshito is traditionally used for the treatment of
gastrointestinal motility disorders, cachexia and nausea. These effects indicate 5-HT3 …

Yokukansan, a traditional Japanese medicine, decreases head-twitch behaviors and serotonin 2A receptors in the prefrontal cortex of isolation-stressed mice

T Ueki, K Mizoguchi, T Yamaguchi, A Nishi… - Journal of …, 2015 - Elsevier
Ethnopharmacological relevance Yokukansan, a traditional Japanese (Kampo) medicine,
has recently been used to treat the behavioral and psychological symptoms of dementia …

Effect of yokukansan, a traditional Japanese medicine, on social and aggressive behaviour of para-chloroamphetamine-injected rats

H Kanno, K Sekiguchi, T Yamaguchi… - Journal of Pharmacy …, 2009 - academic.oup.com
Abstract Objectives Yokukansan, a traditional Japanese medicine, has been approved by
the Ministry of Health, Labour, and Welfare of Japan as a remedy for neurosis, insomnia or …