The receptor pharmacology of amperozide was investigated with in vitro radioligand binding
technique. Amperozide possessed a high affinity to the 5‐HT2 receptors (Ki= 16.5±2.1 nM) …

ETHNOPHARMACOLOGICAL RELEVANCE: Zuojin Pill (ZJP), a traditional Chinese
medicinal decoction, contains two herbal drugs: Coptis chinensis Franch. and Evodia …

MATERIALS AND METHODS Animals Naïve 7-week-old male Wistar rats and 5-week-old
male ddY mice were obtained from Kyudo, Saga, Japan. Animals were housed either in …

Compounds able to discriminate functionally between the closely related cloned human 5-
HT1Dα and 5-HT1Dβ receptor subtypes have not been reported previously. In [3H] 5-HT …

Abstract Serotonin receptor type 3 (5-HT 3 receptor) is a ligand-gated ion channel that is
expressed in the central nervous system (CNS) as well as in the peripheral nervous system …

Traditional Japanese herbal, or Kampo medicine was developed and modified from
Chinese herbal medicine. After the Japanese government approved Kampo for clinical use …

Quantitative receptor autoradiography and behavioral studies were employed to investigate
whether the aqueous extract of Albizzia julibrissin (AEAJ) specifically targets serotonergic …

The pharmacological properties of geissoschizine methyl ether, isolated from Uncaria
sinensis Oliv., were analyzed in vitro and in vivo using mice central serotonin neurons. In the …

The effects of yokukansan, a traditional Japanese medicine, on aggressiveness and motor
activities were examined in mice after injection of amyloid β protein (Aβ) into the lateral …

Abstract Kaixin‐San (KXS), a traditional Chinese medicine, has been used in the treatment
of depression. The present study was undertaken to investigate the effects of an ethanolic …