Ketanserin is the prototypic 5-HT2 serotonin antagonist; although it has been an important
tool for the study of serotonin pharmacology, it has had relatively little impact on drug design …

Human 5-HT1B and 5-HT1D receptors have been implicated as molecular targets for the
treatment of acute migraine based upon the pharmacological actions and clinical efficacy of …

Abstract Toki‐Shakuyaku‐San (TJ‐23) is one of the most popular Kampo medicines in
Japan and it is used for the treatment of ovarian dysfunction and menopausal syndrome in …

Ketanserin has higher affinity for 5-HT1Dα receptors compared to 5-HT1Dβ receptors,
whereas, GR127935 (N-[4-methoxy-3-(4-methyl-1-mpiperazinyl) phenyl]-2 (methyl-4 (-(5 …

The indolonaphthyridine 8 is described as a selective 5-HT2C/2B vs 5-HT2A receptor
antagonist. The compound was synthesized in seven steps starting from indolineand …

Among compounds from natural sources ergolines are of paramount importance as ligands
for serotonin (5-hydroxytryptamine, 5-HT) receptors, dopamine receptors, and …

Agonist and antagonist properties of antipsychotics at human (h) recombinant 5-
hydroxytryptamine (h5-HT1A) receptor have been examined previously in transfected …

The role of 5-HT 1A receptors in the antinociceptive action of 8-hydroxy-2-(di-n-propylamino)
tetralin (8-OH-DPAT) was investigated by using the shock titration test in rats. A …

Synthesis and pharmacological activity of metabolites of the 5-HT4 receptor antagonist SB-207266
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Determination of the optimal assay conditions for the specific binding of a tritiated derivative
of the novel potential anxiolytic drug alnespirone (S-20499,(+)-4-[N-(5-methoxy-chroman-3 …