Hearing loss, including genetic hearing loss, is one of the most common forms of sensory
deficits in humans with limited options of treatment. Adeno-associated virus (AAV)-mediated …

Murine models are ideal for studying cochlear gene transfer, as many hearing loss-related
mutations have been discovered and mapped within the mouse genome. However, because …

The mammalian inner ear consists of diverse cell types with important functions. Gene
mutations in these diverse cell types have been found to underlie different forms of genetic …

Targeting specific cell types in the mammalian inner ear is important for treating genetic
hearing loss due to the different cell type-specific functions. Adeno-associated virus (AAV) is …

Sensorineural hearing loss is one of the most common sensory disorders worldwide. Recent
advances in vector design have paved the way for investigations into the use of adeno …

More than 28 million Americans suffer from various forms of hearing loss. The lack of
effective treatments for many forms of hearing disorders has prompted interest in the …

Background Several genes are candidates for treating inner ear diseases. For clinical
applications, minimally invasive approaches to the inner ear are desirable along with …

Gene therapy strategies using adeno-associated virus (AAV) vectors to treat hereditary
deafnesses have shown remarkable efficacy in some mouse models of hearing loss. Even …

Inner ear gene therapy using adeno-associated viral vectors (AAV) promises to alleviate
hearing and balance disorders. We previously established the benefits of Anc80L65 in …

There are a number of genetic diseases that affect the cochlea early in life, which require
normal gene transfer in the early developmental stage to prevent deafness. The delivery of …