A combination of sorafenib and radiotherapy reduces NF‑κB activity and growth of hepatocellular carcinoma in an orthotopic mouse model

HY Chuang, YS Tyan, JJ Hwang… - Oncology …, 2021 - spandidos-publications.com
Hepatocellular carcinoma (HCC) is difficult to diagnose at an early stage, and its prognosis
is generally poor. Sorafenib is the primary treatment for unresectable advanced HCC and …

[PDF][PDF] Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model

YX Feng, T Wang, YZ Deng, P Yang, JJ Li… - …, 2011 - Wiley Online Library
Surgical resection is the first‐line treatment for hepatocellular carcinoma (HCC) patients with
well‐preserved liver function. Nevertheless, the rate of postoperative recurrence at 5 years is …

[HTML][HTML] Sorafenib pretreatment enhances radiotherapy through targeting MEK/ERK/NF-κB pathway in human hepatocellular carcinoma-bearing mouse model

JCH Chen, HY Chuang, FT Hsu, YC Chen, YC Chien… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Patients with unresectable hepatocellular carcinoma (HCC) usually have poor prognosis
because current monotherapy including surgery, chemotherapy and radiotherapy (RT) are …

Generation and characterization of a sorafenib-resistant hepatocellular carcinoma model from patient-derived tumor xenografts

G Hu, H Fang, X Tang, K Ouyang, X Yang, F Xie… - Cancer Research, 2014 - AACR
Hepatocellular carcinoma (HCC) is a common malignancy worldwide and sorafenib is a
standard of care therapeutics for unresectable HCC. Although sorafenib, a multikinase …

Targeting tumor‐infiltrating Ly6G+ myeloid cells improves sorafenib efficacy in mouse orthotopic hepatocellular carcinoma

CJ Chang, YH Yang, CJ Chiu, LC Lu… - … journal of cancer, 2018 - Wiley Online Library
Sorafenib, a multikinase inhibitor with antiangiogenic activity, is an approved therapy for
hepatocellular carcinoma (HCC). It is unclear whether the proinflammatory and …

Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma

H Huynh, VC Ngo, HN Koong, D Poon… - Journal of cellular …, 2009 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide. Vascular
endothelial growth factor, platelet derived growth factor and the Raf/mitogen‐activated …

Suppression of natural killer cells by sorafenib contributes to prometastatic effects in hepatocellular carcinoma

QB Zhang, HC Sun, KZ Zhang, QA Jia, Y Bu, M Wang… - PLoS …, 2013 - journals.plos.org
Sorafenib, a multi-tyrosine kinase inhibitor, is a standard treatment for advanced
hepatocellular carcinoma (HCC). The present study was undertaken to determine whether …

Comparing the efficacy of sunitinib with sorafenib in xenograft models of human hepatocellular carcinoma: mechanistic explanation

H Huynh, SP Choo, HC Toh, WM Tai… - Current Cancer Drug …, 2011 - ingentaconnect.com
Hepatocellular carcinoma (HCC) is the fifth most common and third deadliest malignancy.
Sorafenib has demonstrated 44% survival advantage over placebo and has emerged as a …

Sorafenib modulates the radio sensitivity of hepatocellular carcinoma cells in vitro in a schedule-dependent manner

Q Li, Y Hu, M Xi, L He, L Zhao, M Liu - BMC cancer, 2012 - Springer
Background Hepatocellular carcinoma (HCC) has a high incidence and mortality.
Radiotherapy and sorafenib have proven effective for HCC. Here, we investigated whether …

Metformin sensitizes sorafenib to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models

A You, M Cao, Z Guo, B Zuo, J Gao, H Zhou… - Journal of hematology & …, 2016 - Springer
Background Sorafenib is recognized as a standard treatment for advanced hepatocellular
carcinoma (HCC). However, many patients have to adopt dose reduction or terminate the …