A combination of sorafenib and radiotherapy reduces NF‑κB activity and growth of hepatocellular carcinoma in an orthotopic mouse model
Hepatocellular carcinoma (HCC) is difficult to diagnose at an early stage, and its prognosis
is generally poor. Sorafenib is the primary treatment for unresectable advanced HCC and …
is generally poor. Sorafenib is the primary treatment for unresectable advanced HCC and …
[PDF][PDF] Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model
Surgical resection is the first‐line treatment for hepatocellular carcinoma (HCC) patients with
well‐preserved liver function. Nevertheless, the rate of postoperative recurrence at 5 years is …
well‐preserved liver function. Nevertheless, the rate of postoperative recurrence at 5 years is …
[HTML][HTML] Sorafenib pretreatment enhances radiotherapy through targeting MEK/ERK/NF-κB pathway in human hepatocellular carcinoma-bearing mouse model
Patients with unresectable hepatocellular carcinoma (HCC) usually have poor prognosis
because current monotherapy including surgery, chemotherapy and radiotherapy (RT) are …
because current monotherapy including surgery, chemotherapy and radiotherapy (RT) are …
Generation and characterization of a sorafenib-resistant hepatocellular carcinoma model from patient-derived tumor xenografts
G Hu, H Fang, X Tang, K Ouyang, X Yang, F Xie… - Cancer Research, 2014 - AACR
Hepatocellular carcinoma (HCC) is a common malignancy worldwide and sorafenib is a
standard of care therapeutics for unresectable HCC. Although sorafenib, a multikinase …
standard of care therapeutics for unresectable HCC. Although sorafenib, a multikinase …
Targeting tumor‐infiltrating Ly6G+ myeloid cells improves sorafenib efficacy in mouse orthotopic hepatocellular carcinoma
CJ Chang, YH Yang, CJ Chiu, LC Lu… - … journal of cancer, 2018 - Wiley Online Library
Sorafenib, a multikinase inhibitor with antiangiogenic activity, is an approved therapy for
hepatocellular carcinoma (HCC). It is unclear whether the proinflammatory and …
hepatocellular carcinoma (HCC). It is unclear whether the proinflammatory and …
Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
H Huynh, VC Ngo, HN Koong, D Poon… - Journal of cellular …, 2009 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide. Vascular
endothelial growth factor, platelet derived growth factor and the Raf/mitogen‐activated …
endothelial growth factor, platelet derived growth factor and the Raf/mitogen‐activated …
Suppression of natural killer cells by sorafenib contributes to prometastatic effects in hepatocellular carcinoma
Sorafenib, a multi-tyrosine kinase inhibitor, is a standard treatment for advanced
hepatocellular carcinoma (HCC). The present study was undertaken to determine whether …
hepatocellular carcinoma (HCC). The present study was undertaken to determine whether …
Comparing the efficacy of sunitinib with sorafenib in xenograft models of human hepatocellular carcinoma: mechanistic explanation
H Huynh, SP Choo, HC Toh, WM Tai… - Current Cancer Drug …, 2011 - ingentaconnect.com
Hepatocellular carcinoma (HCC) is the fifth most common and third deadliest malignancy.
Sorafenib has demonstrated 44% survival advantage over placebo and has emerged as a …
Sorafenib has demonstrated 44% survival advantage over placebo and has emerged as a …
Sorafenib modulates the radio sensitivity of hepatocellular carcinoma cells in vitro in a schedule-dependent manner
Q Li, Y Hu, M Xi, L He, L Zhao, M Liu - BMC cancer, 2012 - Springer
Background Hepatocellular carcinoma (HCC) has a high incidence and mortality.
Radiotherapy and sorafenib have proven effective for HCC. Here, we investigated whether …
Radiotherapy and sorafenib have proven effective for HCC. Here, we investigated whether …
Metformin sensitizes sorafenib to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models
A You, M Cao, Z Guo, B Zuo, J Gao, H Zhou… - Journal of hematology & …, 2016 - Springer
Background Sorafenib is recognized as a standard treatment for advanced hepatocellular
carcinoma (HCC). However, many patients have to adopt dose reduction or terminate the …
carcinoma (HCC). However, many patients have to adopt dose reduction or terminate the …