Hematopoietic stem cell transplantation is becoming an accepted therapy for severe
autoimmune diseases, and over 1000 patients have been transplanted worldwide. Diseases …

Experimental data and early phase I/II studies suggest that high-dose chemotherapy
followed by autologous hematopoietic stem cell transplantation (HSCT) can arrest …

Autologous hematopoietic stem cell transplantation (HSCT) has been used to treat severe
and refractory autoimmune diseases (ADs) in children and adults for more than 15 years …

Numerous individuals and institutions throughout the world have contributed to the
development of hematopoietic stem cell transplantation (HSCT) for autoimmune diseases. In …

Around 700 patients have received an autologous haematopoietic stem cell transplant
(HSCT) as treatment for a severe autoimmune disease (AD). The majority of these have …

Since 1996, a number of investigators have carried out phase I-II studies of high-dose
immunosuppression with autologous hematopoietic stem cell transplantation (HSCT) in …

INTRODUCTION: Autoimmune disease represents a (AD) breakdown of natural tolerance
against autoreactive antigens leading to a high mortality and morbidity. The reaction is …

▪ Abstract The prevalence of autoimmune diseases (ADs) in Western countries is estimated
to be from 3–7%, and the treatment of severe, relapsing/refractory cases is still not …

The practice of stem cell transplantation for severe autoimmune diseases refractory to
conventional therapy originated from two landmark discoveries: the excellent results of …

In this review we report the recent progresses, available in the literature, concerning the
biology and the potential therapeutic role of both mesenchymal stem cells (MSCs) and …