The identification of the retinoblastoma gene (rb) has sparked intense inves tigation of tumor
suppressor genes. These genes, like oncogenes, can encode transcriptional regulators …

Since its discovery, the retinoblastoma (RB) tumour-suppressor protein has been a focal
point of cancer research. Accumulating evidence indicates a complex role for RB in cell …

Mutational inactivation of the retinoblastoma (RB) gene has been implicated in the genesis
of retinoblastoma, osteosarcoma, and other human tumors. Our strategy has been to …

The retinoblastoma gene (RB) is the prototype of a class of genes, called tumor suppressor
genes, for which loss-of-function mutations are oncogenic. Such genes would then normally …

To assess biological roles of the retinoblastoma protein (RB), four independent transgenic
mouse lines expressing human RB with different deletions in the N-terminal region (RBΔN) …

Although the precise function of the retinoblastoma gene product, pl lO P~ 1, remains
unknown, recent data suggest that it plays a role in the control of ceUular proliferation by …

The retinoblastoma (RB) gene is the prototype tumor suppressor gene. It encodes a nuclear
protein that acts as a cell cycle control checkpoint at the G1 phase. Deletion or inactivation of …

Retinoblastoma, an uncommon childhood cancer of the eye, sometimes occurs in families
but is often sporadic. Cytological analysis suggested that the retinoblastoma gene resided …

The retinoblastoma (RB) tumour suppressor gene is functionally inactivated in a broad
range of paediatric and adult cancers, and a plethora of cellular functions and partners have …

The retinoblastoma tumour suppressor protein (Rb) has come a long way since its initial
discovery in 1986. Encoded by the first candidate tumour suppressor gene it has emerged a …