Overexpression of the human multidrug resistance gene 1 (MDR1) is a negative prognostic
factor in leukemia. Despite intense efforts to characterize the gene at the molecular level …

The multidrug resistance 1 gene (MDR1) encodes P-glycoprotein (Pgp), a member of the
ATP-binding cassette (ABC) transporter family that confers tumor drug resistance by actively …

Selection of human cells for resistance to vincristine or doxorubicin often induces
overexpression of the multidrug resistance 1 gene (MDR1), which encodes the cell surface …

The mechanism of action of chemotherapeutic drugs and their ability to induce multidrug
resistance (MDR) are of relevance to cancer treatment. Overexpression of P-glycoprotein …

One of the most important forms of drug resistance in acute myeloid leukemia is the
multidrug resistance (MDR) phenotype, which is characterized by the expression of the …

Multidrug resistance (MDR) is a major problem in patients with hematological malignancies.
Although drug-resistance is known to be induced by the expression of P-glycoprotein (P-gp) …

Chemotherapy is frequently limited by the development of multidrug resistance, a major
cause of which is activation of the P-glycoprotein-encoding MDR1 gene. We have previously …

In recent years, the different classes of drugs and regimens used clinically have provided an
improvement in tumour management. However, treatment is often palliative for the majority …

Resistance to the cytotoxic actions of antineoplastic drugs, whether intrinsic or acquired,
remains a barrier to the establishment of curative chemotherapy regimens for advanced …

The development of multidrug resistance (MDR) in cancer can severely impede the efficacy
of chemotherapy treatment. P-glycoprotein (Pgp) overexpression, encoded by the MDR1 …