The development of multidrug resistance (MDR) in cancer can severely impede the efficacy
of chemotherapy treatment. P-glycoprotein (Pgp) overexpression, encoded by the MDR1 …

Overexpression of the multidrug resistance 1 (MDR1) gene is closely associated with the
clinical outcome of hematopoietic malignancies, but the alteration of its expression during …

The resistance of cancer cells to chemotherapeutic agents is a major clinical problem and
an important cause of treatment failure in cancer. Mechanisms that have developed to guard …

Background The development of resistance to cytotoxic chemotherapy continues to be a
major obstacle for successful anticancer therapy. It has been shown that cells exposed to …

Multidrug resistance in acute myeloid leukemia is often conferred by overexpression of P-
glycoprotein, encoded by the MDR1 gene. We have characterized the key regulatory steps …

Drug resistance caused by overexpression of P-glycoprotein (P-gp), the MDR1 (ABCB1)
gene product, limits the therapeutic outcome. Expression of MDR1 can be induced by …

The multidrug resistance (MDR) phenotype is the major cause of failure of cancer
chemotherapy. This phenotype is mainly due to the overexpression of the human MDR1 …

Failure of chemotherapy in breast cancer presents a major problem and is often due to
elevated expression of ATP binding cassette (ABC)‐type transporters, such as MDR 1 …

We have previously demonstrated in transient expression assay systems that a human
multidrug resistance 1 (MDR1) promoter can be directly activated by cytotoxic anticancer …

In this report, the molecular mechanisms involved in the overexpression of MDR1 mRNA in
the multidrug resistant variant of the HL60 human acute myeloid leukemia cell line …