Abstract The multidrug resistance 1 (MDR1) gene encodes a M (r) 170,000 membrane
glycoprotein termed P-glycoprotein, which catalyzes the energy-dependent efflux of multiple …

Transcriptional silencing of the DNA repair gene, O 6-methylguanine-DNA
methyltransferase (MGMT) in a proportion of transformed cell lines is associated with …

Multidrug resistance protein 1 (MDR1, ABCB1, P-glycoprotein) and breast cancer resistance
protein (BCRP, ABCG2) are key efflux transporters that mediate the extrusion of drugs and …

ABCG2 is an efflux transporter conferring multidrug resistance (MDR) on cancer cells.
However, the initial molecular events leading to its up-regulation in MDR tumor cells are …

Enhanced expression of a multidrug-resistance gene (MDR1) is observed in some cancer
patient, but any regulatory mechanism of MDR1 gene expression in this phenomenon is not …

Gene expression can be regulated by nuclear factors at the transcriptional level. Many such
factors regulate MDR1 gene expression, but what are the sequence elements and …

The development of cross-resistance to many natural product anticancer drugs, termed
multidrug resistance (MDR), is a serious limitation to cancer chemotherapy. MDR is often …

Abstract Background Multidrug resistance 1 (MDR1) gene encodes for an ATP binding
cassette transporter-P-glycoprotein (P-gp)-involved in chemoresistance to taxanes. MDR1 …

Pleiotropic resistance of tumor cells to treatment remains one of the major obstacles for
successful cure of cancer patients. Tumor cells may acquire multidrug resistance (MDR) in …

Abstract Multidrug resistance 1 (MDR1) gene encodes for P-glycoprotein (P-gp), a Mr
170,000 transmembrane calcium-dependent efflux pump that is inactivated in prostate …