The expression of P-glycoproteins encoded by themdr gene family is associated with the
emergence of the multidrug resistance phenotype in animal cells. mdrexpression can be …

Abstract Purpose: Histone deacetylase inhibitors (HDACi) are being studied in clinical trials
with the aim to induce cellular differentiation, growth arrest, and apoptosis of tumor cells …

Amplification and increased expression of the mdr 1 gene associated with multidrug
resistance in human tumors were found in multidrug-resistant sublines of human …

The overexpression of the multidrug resistance gene MDR 1 has been found to be
associated with therapy-resistance in hematological malignancies. Yet the cellular …

Histone acetylation status, an epigenetic determinant of gene transcription, is controlled by
histone acetyltransferases (HATs) and histone deacetylases (HDACs). The potent HDAC …

Quantitative reverse transcriptase polymerase chain reaction (RT-PCR) was used to
determine relative levels of transcripts for MDR1 and the recently described multidrug …

Acquisition of drug resistance is one of the main obstacles encountered in cancer
chemotherapy. Overexpression of multi-drug resistance 1 (MDR1) gene and its protein …

to GABA that was comparable to recep Page 1 G) 1997 Nature Publishing Group http://www.nature.com/naturemedicine
NEWS S VIEWS was found that GABA, receptors containing the ɛ subunit displayed a …

Although combination chemotherapy has had a significant impact on survival for
malignancies such as Hodgkin's disease, testicular cancer, and childhood acute leukemias …

Methylation of the glutathione S-transferase P1 (GSTP1) gene has been described as a
highly specific and sensitive biomarker for prostate cancer. However, at present, it is not …