ALTHOUGH COMBINATION chemotherapy has had a significant impact on survival for
malignancies such as Hodgkin's disease, testicular cancer, and acute childhood …

We investigated the relationship between DNA cytosine methylation and the expression of
two genes associated with resistance to DNA methylation damage. Variants of RajiMex-cells …

In the last few years, DNA methylation has become one of the most studied gene regulation
mechanisms in carcinogenesis as a result of the cumulative evidence produced by the …

We investigated the mechanism of sodium butyrate (NaB)-mediated induction of mdr1
mRNA in parental (wild type) and multidrug-resistant (Ad1000) SW620 colon cancer cell …

Expression of the multidrug resistance gene mdr1 is reported to be an important determinant
of responsiveness to therapy and survival in some cancers. Many different methods have …

Multidrug resistance (MDR) mediated by overexpression of the MDR protein (P-
glycoprotein) has been associated with intracellular alkalinization, membrane …

Departments of Molecular Pharmacology and Cell Biology, Albert Einstein College of
Medicine, Bronx, New York 10461 Received July 23, 1987; Revised Manuscript Received …

Methylation-controlled J protein (MCJ) is a newly identified member of the DnaJ family of
cochaperones. Hypermethylation-mediated transcriptional silencing of the MCJ gene has …

The expression of P-glycoprotein (Pgp) is often increased in acute myeloid leukemia (AML).
However, little is known of the regulation of Pgp expression by cytotoxics in AML. We …

Many cancers have been cured by chemotherapeutic agents. However, other cancers are
intrinsically drug resistant, and some acquire resistance following chemotherapy. Cloning of …