Stress-induced EGFR trafficking: mechanisms, functions, and therapeutic implications
Epidermal growth factor receptor (EGFR) has fundamental roles in normal physiology and
cancer, making it a rational target for cancer therapy. Surprisingly, however, inhibitors that …
cancer, making it a rational target for cancer therapy. Surprisingly, however, inhibitors that …
EGFR signaling pathway as therapeutic target in human cancers
Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations
W Han, HW Lo - Cancer letters, 2012 - Elsevier
The epidermal growth factor receptor (EGFR) pathway is one of the most dysregulated
molecular pathways in human cancers. Despite its well-established importance in tumor …
molecular pathways in human cancers. Despite its well-established importance in tumor …
Emerging functions of the EGFR in cancer
S Sigismund, D Avanzato, L Lanzetti - Molecular oncology, 2018 - Wiley Online Library
The physiological function of the epidermal growth factor receptor (EGFR) is to regulate
epithelial tissue development and homeostasis. In pathological settings, mostly in lung and …
epithelial tissue development and homeostasis. In pathological settings, mostly in lung and …
EGFR trafficking in physiology and cancer
G Caldieri, MG Malabarba, PP Di Fiore… - Endocytosis and …, 2018 - Springer
Signaling from the epidermal growth factor receptor (EGFR) elicits multiple biological
responses, including cell proliferation, migration, and survival. Receptor endocytosis and …
responses, including cell proliferation, migration, and survival. Receptor endocytosis and …
The complexity of targeting EGFR signalling in cancer: from expression to turnover
S Sebastian, J Settleman, SJ Reshkin, A Azzariti… - … et Biophysica Acta (BBA …, 2006 - Elsevier
The epidermal growth factor receptor (ErbB1 or EGFR) has been found to be altered in a
variety of human cancers. A number of agents targeting these receptors, including specific …
variety of human cancers. A number of agents targeting these receptors, including specific …
EGF receptor trafficking: consequences for signaling and cancer
A Tomas, CE Futter, ER Eden - Trends in cell biology, 2014 - cell.com
The ligand-stimulated epidermal growth factor receptor (EGFR) has been extensively
studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of …
studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of …
Biology of interactions: antiepidermal growth factor receptor agents
PM Harari, GW Allen, JA Bonner - Journal of Clinical Oncology, 2007 - ascopubs.org
Epidermal growth factor receptor (EGFR) signaling inhibition represents a highly promising
arena for the application of molecularly targeted cancer therapies. Evolving from several …
arena for the application of molecularly targeted cancer therapies. Evolving from several …
p38 MAP kinase mediates stress‐induced internalization of EGFR: implications for cancer chemotherapy
Y Zwang, Y Yarden - The EMBO journal, 2006 - embopress.org
The epidermal growth factor receptor (EGFR) frequently associates with cancer and already
serves as a target for therapy. We report that inflammatory cytokines and ultraviolet (UV) …
serves as a target for therapy. We report that inflammatory cytokines and ultraviolet (UV) …
Crosstalk between epidermal growth factor receptor-and insulin-like growth factor-1 receptor signaling: implications for cancer therapy
Both the epidermal growth factor receptor (EGFR) and the insulin-like growth factor-1
receptor (IGF-1R) can contribute to tumor development and-progression through their effects …
receptor (IGF-1R) can contribute to tumor development and-progression through their effects …