Epidermal growth factor (EGF) receptor (EGFR) signalling regulates diverse cellular
functions, promoting cell proliferation, differentiation, migration, cell growth and survival …

Dysregulation of human epidermal growth factor receptor (ErbB/HER) pathways by over-
expression or constitutive activation can promote tumor processes including angiogenesis …

Introduction: Cancer is a devastating disease; however, several therapeutic advances have
recently been made, wherein EGFR and its family members have emerged as useful …

EGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis.
Following ligand binding, EGFR stimulates downstream cell signaling cascades that …

Aberrant expression, activation, and stabilization of epidermal growth factor receptor (EGFR)
are causally associated with several human cancers. Post-translational modifications and …

EGFR is a trans-membrane receptor tyrosine kinase that belongs to the HER family of
receptors. The EGFR family plays an essential role in normal organ development by …

The discovery that signaling by the epidermal growth factor receptor (EGFR) plays a key role
in tumorigenesis prompted efforts to target this receptor in anticancer therapy. Two different …

The Epidermal growth factor receptor (EGFR) is a membrane spanning glycoprotein, which
frequently has been implicated in various cancer types. The mechanisms by which EGFR …

The epidermal growth factor receptor (EGFR) is overexpressed and/or constitutively
activated in a variety of human malignancies. Detection of increased expression levels of …

A major question regarding the sensitivity of solid tumors to targeted kinase inhibitors is why
some tumors respond and others do not. The observation that many tumors express EGF …