Proteolysis via the ubiquitin system plays important roles in a variety of basic cellular
processes. Among these are regulation of cell cycle and division, modulation of the immune …

The ubiquitin proteolytic system plays an important role in a broad array of basic cellular
processes. Among these are regulation of cell cycle, modulation of the immune and …

Ubiquitin modification of many protein targets within cells plays important roles in a variety of
biological processes. Among these are regulation of gene expression, regulation of cell …

Ubiquitin modification of a variety of protein targets within the cell plays important roles in
many cellular processes. Among these are regulation of gene expression, regulation of cell …

With the many processes and substrates targeted by the ubiquitin pathway, it is not
surprising to find that aberrations in the system underlie, directly or indirectly, the …

▪ Abstract A growing number of cellular regulatory mechanisms are being linked to protein
modification by the polypeptide ubiquitin. These include key transitions in the cell cycle …

The post-translational modification of proteins by covalent attachment of ubiquitin targets
these proteins for degradation by the proteasome. An astounding number of proteins are …

To understand the mechanisms underlying the remarkable selectivity and regulation of
intracellular protein breakdown, the identification and character ization of the enzymatic …

Mammalian cells contain two distinct proteolytic pathways that are involved in different
aspects of protein breakdown. Proteins that enter the cell from the extracellular milieu (such …

Eukaryotes contain a highly conserved multi-enzyme system that covalently links ubiquitin to
a variety of intracellular proteins that bear degradation signals recognized by this system …