A series of novel 4-arylamino-6-(5-substituted furan-2-yl) quinazoline derivatives were
designed, synthesized and evaluated on biological activities in vitro. Compound 2a, 3a and …

Abstract A series of novel 6, 7-dimorpholinoalkoxy quinazoline derivatives was designed,
synthesized and evaluated as potent EGFR inhibitors. Most of synthesized derivatives …

Eight series of quinazoline derivatives bearing 2, 3-dihydro-indole or 1, 2, 3, 4-
tetrahydroquinoline were designed, synthesized and evaluated for the IC 50 values against …

anilinoquinazoline-based derivatives represent an attractive scaffold for small molecular
EGFR-TKIs in the field of medicinal chemistry. A series of novel heterocyclic substituted …

A type of novel 4, 6-substituted-(diaphenylamino) quinazolines, which designed based on
the 4-(phenylamino) quinazoline moiety, have been discovered as potential EGFR …

Abstract Series of 4-anilinoquinazoline derivatives were conveniently and efficiently
synthesized and their antitumor activities were evaluated by MTT assay in three human …

The in vitro anticancer efficacy of a new series of quinazoline-based thiazole derivatives was
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …

A series of novel 4-anilinoquinazoline derivatives with (E)-propen-1-yl moiety were
designed, synthesized and evaluated for biological activities in vitro. Most compounds …

The present study describes the synthesis of 6-bromo-2-(pyridin-3-yl)-4-substituted
quinazolines starting from 4-chloro derivative VI via the reaction with either phenolic …

A series of novel thiapyran-pyrimidine derivatives (10a–10h, 11a–11g, 12a–12f, 13a–13f,
14a–14f) were synthesized and their antiproliferative activities were tested. Most of the target …