Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation

AC Raddant, AF Russo - Expert reviews in molecular medicine, 2011 - cambridge.org
Over the past two decades, a convergence of basic and clinical evidence has established
the neuropeptide calcitonin-gene-related peptide (CGRP) as a key player in migraine …

Calcitonin gene-related peptide and migraine

N Karsan, PJ Goadsby - Current opinion in neurology, 2015 - journals.lww.com
This article highlights the evidence behind the role of CGRP in migraine and the state of
CGRP-based mechanism treatment development. We present a summary of the evidence …

Diverse physiological roles of calcitonin gene-related peptide in migraine pathology: modulation of neuronal-glial-immune cells to promote peripheral and central …

PL Durham - Current pain and headache reports, 2016 - Springer
The neuropeptide calcitonin gene-related peptide (CGRP) is implicated in the underlying
pathology of migraine by promoting the development of a sensitized state of primary and …

CGRP in human models of migraine

H Ashina, HW Schytz, M Ashina - Calcitonin Gene-Related Peptide …, 2019 - Springer
Over the past three decades, calcitonin gene-related peptide (CGRP) has emerged as a key
molecule. Provocation experiments have demonstrated that intravenous CGRP infusion …

Calcitonin gene-related peptide (CGRP): a new target for migraine

AF Russo - Annual review of pharmacology and toxicology, 2015 - annualreviews.org
Migraine is a neurological disorder that manifests as a debilitating headache associated
with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) …

Calcitonin gene‐related peptide (CGRP) and migraine current understanding and state of development

ME Bigal, S Walter, AM Rapoport - Headache: The Journal of …, 2013 - Wiley Online Library
Calcitonin gene‐related peptide (CGRP) is a ubiquitous neuropeptide found at the very
centers of the migraine process, both centrally and peripherally. It has been under careful …

[HTML][HTML] The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine

S Iyengar, MH Ossipov, KW Johnson - Pain, 2017 - journals.lww.com
Calcitonin gene–related peptide (CGRP) is a 37-amino acid peptide found primarily in the C
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …

Calcitonin gene‐related peptide (CGRP) and migraine

PL Durham - Headache: The Journal of Head and Face Pain, 2006 - Wiley Online Library
The neuropeptide calcitonin gene‐related peptide (CGRP) has long been postulated to play
an integral role in the pathophysiology of migraine. While clinical findings are consistent with …

Calcitonin gene-related peptide: an update on the biology

A Recober, AF Russo - Current opinion in neurology, 2009 - journals.lww.com
The advent of CGRP receptor antagonists as a novel therapy for migraine attacks may
represent a new era in the acute management of migraine. More than a simple addition to …

Calcitonin gene-related peptide (CGRP): role in migraine pathophysiology and therapeutic targeting

AS Wattiez, LP Sowers, AF Russo - Expert opinion on therapeutic …, 2020 - Taylor & Francis
Introduction: The neuropeptide calcitonin gene-related peptide (CGRP) is recognized as a
critical player in migraine pathophysiology. Excitement has grown regarding CGRP because …