When Is It Appropriate to Take Off the Mask? Signaling Pathways That Regulate ß(1,3)-Glucan Exposure in Candida albicans
T Chen, AS Wagner, TB Reynolds - Frontiers in fungal biology, 2022 - frontiersin.org
Candida spp. are an important source of systemic and mucosal infections in immune
compromised populations. However, drug resistance or toxicity has put limits on the efficacy …
compromised populations. However, drug resistance or toxicity has put limits on the efficacy …
Nature of β-1, 3-glucan-exposing features on Candida albicans cell wall and their modulation
Candida albicans exists as a commensal of mucosal surfaces and the gastrointestinal tract
without causing pathology. However, this fungus is also a common cause of mucosal and …
without causing pathology. However, this fungus is also a common cause of mucosal and …
Revisiting the Vital Drivers and Mechanisms of β-Glucan Masking in Human Fungal Pathogen, Candida albicans
S Hameed, S Hans, S Singh, R Dhiman, R Monasky… - Pathogens, 2021 - mdpi.com
Among the several human fungal pathogens, Candida genus represents one of the most
implicated in the clinical scenario. There exist several distinctive features that govern the …
implicated in the clinical scenario. There exist several distinctive features that govern the …
Dynamic, Morphotype-Specific Candida albicans β-Glucan Exposure during Infection and Drug Treatment
RT Wheeler, D Kombe, SD Agarwala, GR Fink - PLoS pathogens, 2008 - journals.plos.org
Candida albicans, a clinically important dimorphic fungal pathogen that can evade immune
attack by masking its cell wall β-glucan from immune recognition, mutes protective host …
attack by masking its cell wall β-glucan from immune recognition, mutes protective host …
Caspofungin-induced β(1,3)-glucan exposure in Candida albicans is driven by increased chitin levels
AS Wagner, SW Lumsdaine, MM Mangrum… - Mbio, 2023 - Am Soc Microbiol
To successfully induce disease, Candida albicans must effectively evade the host immune
system. One mechanism used by C. albicans to achieve this is to mask immunogenic β (1, 3) …
system. One mechanism used by C. albicans to achieve this is to mask immunogenic β (1, 3) …
Activation of Cph1 causes ß(1,3)-glucan unmasking in Candida albicans and attenuates virulence in mice in a neutrophil-dependent manner
AS Wagner, TJ Hancock, SW Lumsdaine… - PLoS …, 2021 - journals.plos.org
Masking the immunogenic cell wall epitope ß (1, 3)-glucan under an outer layer of
mannosylated glycoproteins is an important virulence factor deployed by Candida albicans …
mannosylated glycoproteins is an important virulence factor deployed by Candida albicans …
Cek1 regulates ß(1,3)-glucan exposure through calcineurin effectors in Candida albicans
AS Wagner, SW Lumsdaine, MM Mangrum… - PLoS …, 2022 - journals.plos.org
In order to successfully induce disease, the fungal pathogen Candida albicans regulates
exposure of antigens like the cell wall polysaccharide ß (1, 3)-glucan to the host immune …
exposure of antigens like the cell wall polysaccharide ß (1, 3)-glucan to the host immune …
Exposure of Candida albicans β (1,3)-glucan is promoted by activation of the Cek1 pathway
T Chen, JW Jackson, RN Tams, SE Davis… - PLoS …, 2019 - journals.plos.org
Candida albicans is among the most common causes of human fungal infections and is an
important source of mortality. C. albicans is able to diminish its detection by innate immune …
important source of mortality. C. albicans is able to diminish its detection by innate immune …
Epitope shaving promotes fungal immune evasion
DS Childers, GM Avelar, JM Bain, A Pradhan… - MBio, 2020 - Am Soc Microbiol
The cell wall provides a major physical interface between fungal pathogens and their
mammalian host. This extracellular armor is critical for fungal cell homeostasis and survival …
mammalian host. This extracellular armor is critical for fungal cell homeostasis and survival …
[PDF][PDF] Epitope shaving promotes fungal immune evasion. mBio 11: e00984-20
DS Childers, GM Avelar, JM Bain… - DOI: https://doi. org …, 2020 - ore.exeter.ac.uk
The cell wall provides a major physical interface between fungal pathogens and their
mammalian host. This extracellular armor is critical for fungal cell homeostasis and survival …
mammalian host. This extracellular armor is critical for fungal cell homeostasis and survival …