Although opioid use disorders and overdose have been long-term global health problems,
the United States has experienced an unprecedented opioid crisis over the early part of the …

The impact of opioid use and overdose on our communities has become part of the daily
discourse in the United States. Among the over 64,000 drug-overdose deaths estimated in …

Over the past several decades, opioid overdose deaths have become an increasing issue in
the United States, contributing to the opioid epidemic and challenging the health system and …

Background: The opioid epidemic in the United States is a problem that has developed over
decades. While clinical, regulatory, and legislative changes have been implemented to …

Abstract Purpose of Review In the USA, there has been a sharp increase in heroin,
prescription opiate, and illicitly manufactured fentanyl abuse with overdoses tripling since …

Background The harms related to nonmedical use of opioid analgesics have impacted the
United States for more than a decade. Examining trends in nonmedical use, abuse, and …

Public health experts increasingly agree that “the misuse of and addiction to opioids—
including prescription pain medicines, heroin, and synthetic opioids such as fentanyl—is a …

The class of substances described as opioids includes natural and synthetic opioid drugs
such as those that are available by prescription (eg, morphine, methadone, codeine …

The US opioid epidemic has changed profoundly in the last 3 years, in ways that require
substantial recalibration of the US policy response. This report summarizes the changing …

Not since the HIV/AIDS epidemic has the United States faced as devastating and lethal a
health problem as the current crisis of opioid misuse and overdose and opioid use disorder …