iPSC-derived natural killer cell therapies-expansion and targeting
Treatment of cancer with allogeneic natural killer (NK) cell therapies has seen rapid
development, especially use against hematologic malignancies. Clinical trials of NK cell …
development, especially use against hematologic malignancies. Clinical trials of NK cell …
Off-the-shelf cell therapy with induced pluripotent stem cell-derived natural killer cells
ML Saetersmoen, Q Hammer, B Valamehr… - Seminars in …, 2019 - Springer
Cell therapy is emerging as a very promising therapeutic modality against cancer,
spearheaded by the clinical success of chimeric antigen receptor (CAR) modified T cells for …
spearheaded by the clinical success of chimeric antigen receptor (CAR) modified T cells for …
[HTML][HTML] Engineered natural killer cells expressing chimeric antigen receptors (CAR)—a promising approach in tumor immunotherapy
B Neuber, M Schmitt - Biotarget, 2019 - biotarget.amegroups.org
Engineered natural killer cells expressing chimeric antigen receptors (CAR)—a promising
approach in tumor immunotherapy - Neuber - Biotarget Have a website account?Log In orRegister …
approach in tumor immunotherapy - Neuber - Biotarget Have a website account?Log In orRegister …
1206 Immunometabolic modulation of engineered iPSC-NK cells for immunotherapy of solid tumors
S Borde, S Matosevic - 2023 - jitc.bmj.com
Background Natural killer (NK) cells have efficient intrinsic recognition capabilities toward
abnormal cells. This fact makes them particularly attractive as safe effector cells for cancer …
abnormal cells. This fact makes them particularly attractive as safe effector cells for cancer …
Methods of treating hematological disorders, solid tumors, or infectious diseases using natural killer cells
K Lin, X Zhang, J Harris, V Jankovic - 2018 - Google Patents
EP3240551A4 - Methods of treating hematological disorders, solid tumors, or infectious
diseases using natural killer cells - Google Patents EP3240551A4 - Methods of treating …
diseases using natural killer cells - Google Patents EP3240551A4 - Methods of treating …
IMMUNOTHERAPIES USING ENHANCED iPSC DERIVED EFFECTOR CELLS
B Valamehr, R Bjordahl, TT Lee… - US Patent App. 16 …, 2021 - Google Patents
2020-05-29 Assigned to FATE THERAPEUTICS, INC. reassignment FATE THERAPEUTICS,
INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS) …
INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS) …
iPSC-BASED IMMUNOTHERAPY DIFFERENTIATION PLATFORM ENABLES FEEDER-FREE EXPANSION OF NK CELLS TO CLINICAL SCALE
D Terheyden-Keighley, B Hiller, A Gamerschlag… - Cytotherapy, 2024 - Elsevier
Background & Aim Human induced pluripotent stem cells (iPSCs) are emerging as a potent
starting material for allogeneic cell therapies. As a prerequisite, we have established a GMP …
starting material for allogeneic cell therapies. As a prerequisite, we have established a GMP …
Developing the next generation of iPSC cell-based immunotherapies
T cells are potentially curative for patients with metastatic cancer, but many patients with
cancer have T cells that are'terminally differentiated', a condition associated with treatment …
cancer have T cells that are'terminally differentiated', a condition associated with treatment …
[PDF][PDF] New strategies to improve Natural Killer cells for “off-the-shelf” allogeneic immunotherapy
K Hörster - 2022 - scholar.archive.org
Figure 1: Linear model of NK cell development. NK cells share the common lymphoid
progenitor with B cells, T cells and innate lymphoid cells (ILC). Acquisition of IL2RB/CD122 …
progenitor with B cells, T cells and innate lymphoid cells (ILC). Acquisition of IL2RB/CD122 …
Selectively and Efficiently Expanding Natural Killer Cells in Vitro
X Lu, J Liu, J Zhuxia, X Ouyang, B Chen - Blood, 2020 - Elsevier
Natural killer (NK) cells are the main innate immune cells, and have powerful antitumor
activity in vitro, but NK cells based immunotherapy does not often get satisfactory results in …
activity in vitro, but NK cells based immunotherapy does not often get satisfactory results in …