[HTML][HTML] Cord blood derived natural killer cells engineered with a chimeric antigen receptor targeting CD19 and expressing IL-15 have long term persistence and exert …
Natural killer (NK) cells are a major component of the innate immune system, possessing the
ability to lyse their targets without the need for prior sensitization or specificity for antigen …
ability to lyse their targets without the need for prior sensitization or specificity for antigen …
[HTML][HTML] Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy
KV Woan, H Kim, R Bjordahl, ZB Davis, S Gaidarova… - Cell Stem Cell, 2021 - cell.com
Select subsets of immune effector cells have the greatest propensity to mediate antitumor
responses. However, procuring these subsets is challenging, and cell-based …
responses. However, procuring these subsets is challenging, and cell-based …
[HTML][HTML] Overcoming the challenges in translational development of natural killer cell therapeutics: An opinion paper
H Qin, C You, F Yan, K Tan, C Xu, R Zhao… - Frontiers in …, 2022 - frontiersin.org
Cellular therapies have attracted huge research and clinical attention lately (1, 2). Natural
killer cells (NKCs) are a class of innate immune lymphoid cells (ILP) mainly derived from …
killer cells (NKCs) are a class of innate immune lymphoid cells (ILP) mainly derived from …
[HTML][HTML] Natural killer cells: from basic research to treatments
The immune system is classically divided into innate and adaptive. Adaptive immunity can
be defined by the presence of cells (ie, T and B lymphocytes in higher vertebrates) that …
be defined by the presence of cells (ie, T and B lymphocytes in higher vertebrates) that …
Highlight of 2023: Unlocking the therapeutic potential of natural killer cells-advances in adaptive functions, cellular engineering and immunotherapy.
PY Lam… - Immunology and Cell …, 2024 - europepmc.org
Natural killer (NK) cells possess potent cytotoxicity against infected and cancerous cells and
hold promise in the development of new immunotherapies. This article for the Highlights of …
hold promise in the development of new immunotherapies. This article for the Highlights of …
[HTML][HTML] An alternative cell therapy for cancers: induced pluripotent stem cell (iPSC)-derived natural killer cells
Cell therapy is usually defined as the treatment or prevention of human disease by
supplementation with cells that have been selected, manipulated, and pharmacologically …
supplementation with cells that have been selected, manipulated, and pharmacologically …
Generation of Natural Killer Cells from Human Expanded Potential Stem Cells
PY Ching, C Wang, S Hang, P Liu… - JoVE (Journal of Visualized …, 2023 - jove.com
The differentiation of natural killer (NK) cells from human pluripotent stem cells allows for
research on and the manufacture of clinical-grade cellular products for immunotherapy …
research on and the manufacture of clinical-grade cellular products for immunotherapy …
[HTML][HTML] iPSC-derived natural killer cells for cancer immunotherapy
P Karagiannis, SI Kim - Molecules and cells, 2021 - Elsevier
The discovery of human pluripotent stem cells (PSCs) at the turn of the century opened the
door to a new generation of regenerative medicine research. Among PSCs, the donors …
door to a new generation of regenerative medicine research. Among PSCs, the donors …
[PDF][PDF] Cytokine-autonomous, CAR-directed, off-the-shelf natural killer cells derived from a clonal engineered master pluripotent cell line
Natural killer (NK) cells are potent anti-tumor effectors that play an important role in innate
and adaptive immunity. Despite recent clinical advances in the therapeutic use of NK cells …
and adaptive immunity. Despite recent clinical advances in the therapeutic use of NK cells …