[HTML][HTML] Cord blood derived natural killer cells engineered with a chimeric antigen receptor targeting CD19 and expressing IL-15 have long term persistence and exert …

E Liu, Y Tong, G Dotti, B Savoldo, M Muftuoglu… - Blood, 2015 - Elsevier
Natural killer (NK) cells are a major component of the innate immune system, possessing the
ability to lyse their targets without the need for prior sensitization or specificity for antigen …

[引用][C] iPSC-derived natural killer cell therapies-expansion and targeting. Front Immunol. 2022; 13: 841107

BH Goldenson, P Hor, DS Kaufman - 2022

[HTML][HTML] Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy

KV Woan, H Kim, R Bjordahl, ZB Davis, S Gaidarova… - Cell Stem Cell, 2021 - cell.com
Select subsets of immune effector cells have the greatest propensity to mediate antitumor
responses. However, procuring these subsets is challenging, and cell-based …

[HTML][HTML] Overcoming the challenges in translational development of natural killer cell therapeutics: An opinion paper

H Qin, C You, F Yan, K Tan, C Xu, R Zhao… - Frontiers in …, 2022 - frontiersin.org
Cellular therapies have attracted huge research and clinical attention lately (1, 2). Natural
killer cells (NKCs) are a class of innate immune lymphoid cells (ILP) mainly derived from …

[HTML][HTML] Natural killer cells: from basic research to treatments

E Vivier, S Ugolini - Frontiers in immunology, 2011 - frontiersin.org
The immune system is classically divided into innate and adaptive. Adaptive immunity can
be defined by the presence of cells (ie, T and B lymphocytes in higher vertebrates) that …

Highlight of 2023: Unlocking the therapeutic potential of natural killer cells-advances in adaptive functions, cellular engineering and immunotherapy.

PY Lam… - Immunology and Cell …, 2024 - europepmc.org
Natural killer (NK) cells possess potent cytotoxicity against infected and cancerous cells and
hold promise in the development of new immunotherapies. This article for the Highlights of …

[HTML][HTML] An alternative cell therapy for cancers: induced pluripotent stem cell (iPSC)-derived natural killer cells

LJ Hsu, CL Liu, ML Kuo, CN Shen, CR Shen - Biomedicines, 2021 - mdpi.com
Cell therapy is usually defined as the treatment or prevention of human disease by
supplementation with cells that have been selected, manipulated, and pharmacologically …

Generation of Natural Killer Cells from Human Expanded Potential Stem Cells

PY Ching, C Wang, S Hang, P Liu… - JoVE (Journal of Visualized …, 2023 - jove.com
The differentiation of natural killer (NK) cells from human pluripotent stem cells allows for
research on and the manufacture of clinical-grade cellular products for immunotherapy …

[HTML][HTML] iPSC-derived natural killer cells for cancer immunotherapy

P Karagiannis, SI Kim - Molecules and cells, 2021 - Elsevier
The discovery of human pluripotent stem cells (PSCs) at the turn of the century opened the
door to a new generation of regenerative medicine research. Among PSCs, the donors …

[PDF][PDF] Cytokine-autonomous, CAR-directed, off-the-shelf natural killer cells derived from a clonal engineered master pluripotent cell line

TT Lee, YE Li, R Bjordahl, R Blum, S Mahmood… - Cancer Res, 2018 - researchgate.net
Natural killer (NK) cells are potent anti-tumor effectors that play an important role in innate
and adaptive immunity. Despite recent clinical advances in the therapeutic use of NK cells …