Hematopoietic stem cell-and induced pluripotent stem cell-derived CAR-NK cells as reliable cell-based therapy solutions
J Arias, J Yu, M Varshney, J Inzunza… - Stem Cells …, 2021 - academic.oup.com
Hematopoietic stem cell-(HSC) and induced pluripotent stem (iPS) cell-derived natural killer
(NK) cells containing engineered functions, such as chimeric antigen receptors (CAR), offer …
(NK) cells containing engineered functions, such as chimeric antigen receptors (CAR), offer …
Natural killer cells and uses thereof
E Law, L Kang, V Jankovic, X Zhang… - US Patent App. 14 …, 2015 - Google Patents
2018-08-23 Assigned to ANTHROGENESIS CORPORATION reassignment
ANTHROGENESIS CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE …
ANTHROGENESIS CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE …
Natural killer cell–based immunotherapy: from transplantation toward targeting cancer stem cells
H Dianat‐Moghadam, M Rokni, F Marofi… - Journal of cellular …, 2019 - Wiley Online Library
Natural killer (NK) cells are key players of the innate immune system. NK cells provide
protection against infectious pathogens and malignancies in cell. This characteristic may be …
protection against infectious pathogens and malignancies in cell. This characteristic may be …
Artificial antigen presenting cell (aAPC) mediated activation and expansion of natural killer T cells
JE East, W Sun, TJ Webb - JoVE (Journal of Visualized Experiments), 2012 - jove.com
Natural killer T (NKT) cells are a unique subset of T cells that display markers characteristic
of both natural killer (NK) cells and T cells1. Unlike classical T cells, NKT cells recognize …
of both natural killer (NK) cells and T cells1. Unlike classical T cells, NKT cells recognize …
[HTML][HTML] FT596: translation of first-of-kind multi-antigen targeted off-the-shelf CAR-NK cell with engineered persistence for the treatment of B cell malignancies
Induced pluripotent stem cell (iPSC)-derived effector cells offer distinct advantages for
immune therapy over existing patient-or donor-derived platforms, both in terms of scalable …
immune therapy over existing patient-or donor-derived platforms, both in terms of scalable …
CD19/CD20 dual-targeted chimeric antigen receptor-engineered natural killer cells exhibit improved cytotoxicity against acute lymphoblastic leukemia
N Yang, C Zhang, Y Zhang, Y Fan, J Zhang… - Journal of Translational …, 2024 - Springer
Background Chimeric antigen receptor natural killer (CAR-NK) cells represent a promising
advancement in CAR cell therapy, addressing limitations observed in CAR-T cell therapy …
advancement in CAR cell therapy, addressing limitations observed in CAR-T cell therapy …
[HTML][HTML] The emerging role of off-the-shelf engineered natural killer cells in targeted cancer immunotherapy
Natural killer (NK) cells are innate lymphocytes that recognize and clear infected and
transformed cells. The importance of NK cells in tumor surveillance underlies the …
transformed cells. The importance of NK cells in tumor surveillance underlies the …
169 Off-the-shelf, engineered iPSC-derived NK cells mediate potent cytotoxic activity against primary glioblastoma cells and promote durable long-term survival in vivo
F Cichocki, J Ning, Z Davis, H Wang, K Tuininga… - 2021 - jitc.bmj.com
Background Glioblastoma multiforme (GBM) is a primary brain tumor with a high mortality
rate and median survival of~ 14 months. Although progress has been made in the …
rate and median survival of~ 14 months. Although progress has been made in the …
FT538, iPSC-Derived NK Cells Are Potent Inducers of Apoptosis in AML Cells and Their Effect Is Synergistic in Combination with Approved Therapeutic Strategies
Background: Natural killer (NK) cell-based therapies have been increasingly studied with
their advantages of less treatment-related toxicity and lack of HLA restriction. Induced …
their advantages of less treatment-related toxicity and lack of HLA restriction. Induced …
Differentiation of natural killer cells from induced pluripotent stem cells under defined, serum-and feeder-free conditions
KB Lupo, JI Moon, AM Chambers, S Matosevic - Cytotherapy, 2021 - Elsevier
Background aims Traditionally, natural killer (NK) cells are sourced from the peripheral
blood of donors―a laborious and highly donor-specific process. Processes for generating …
blood of donors―a laborious and highly donor-specific process. Processes for generating …