Hematopoietic stem cell-and induced pluripotent stem cell-derived CAR-NK cells as reliable cell-based therapy solutions

J Arias, J Yu, M Varshney, J Inzunza… - Stem Cells …, 2021 - academic.oup.com
Hematopoietic stem cell-(HSC) and induced pluripotent stem (iPS) cell-derived natural killer
(NK) cells containing engineered functions, such as chimeric antigen receptors (CAR), offer …

Natural killer cells and uses thereof

E Law, L Kang, V Jankovic, X Zhang… - US Patent App. 14 …, 2015 - Google Patents
2018-08-23 Assigned to ANTHROGENESIS CORPORATION reassignment
ANTHROGENESIS CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE …

Natural killer cell–based immunotherapy: from transplantation toward targeting cancer stem cells

H Dianat‐Moghadam, M Rokni, F Marofi… - Journal of cellular …, 2019 - Wiley Online Library
Natural killer (NK) cells are key players of the innate immune system. NK cells provide
protection against infectious pathogens and malignancies in cell. This characteristic may be …

Artificial antigen presenting cell (aAPC) mediated activation and expansion of natural killer T cells

JE East, W Sun, TJ Webb - JoVE (Journal of Visualized Experiments), 2012 - jove.com
Natural killer T (NKT) cells are a unique subset of T cells that display markers characteristic
of both natural killer (NK) cells and T cells1. Unlike classical T cells, NKT cells recognize …

[HTML][HTML] FT596: translation of first-of-kind multi-antigen targeted off-the-shelf CAR-NK cell with engineered persistence for the treatment of B cell malignancies

JP Goodridge, S Mahmood, H Zhu, S Gaidarova… - Blood, 2019 - Elsevier
Induced pluripotent stem cell (iPSC)-derived effector cells offer distinct advantages for
immune therapy over existing patient-or donor-derived platforms, both in terms of scalable …

CD19/CD20 dual-targeted chimeric antigen receptor-engineered natural killer cells exhibit improved cytotoxicity against acute lymphoblastic leukemia

N Yang, C Zhang, Y Zhang, Y Fan, J Zhang… - Journal of Translational …, 2024 - Springer
Background Chimeric antigen receptor natural killer (CAR-NK) cells represent a promising
advancement in CAR cell therapy, addressing limitations observed in CAR-T cell therapy …

[HTML][HTML] The emerging role of off-the-shelf engineered natural killer cells in targeted cancer immunotherapy

KP Fabian, JW Hodge - Molecular Therapy-Oncolytics, 2021 - cell.com
Natural killer (NK) cells are innate lymphocytes that recognize and clear infected and
transformed cells. The importance of NK cells in tumor surveillance underlies the …

169 Off-the-shelf, engineered iPSC-derived NK cells mediate potent cytotoxic activity against primary glioblastoma cells and promote durable long-term survival in vivo

F Cichocki, J Ning, Z Davis, H Wang, K Tuininga… - 2021 - jitc.bmj.com
Background Glioblastoma multiforme (GBM) is a primary brain tumor with a high mortality
rate and median survival of~ 14 months. Although progress has been made in the …

FT538, iPSC-Derived NK Cells Are Potent Inducers of Apoptosis in AML Cells and Their Effect Is Synergistic in Combination with Approved Therapeutic Strategies

A Eckstrom, A Tyagi, M Siddiqui, S Mahmood, L Wong… - Blood, 2023 - Elsevier
Background: Natural killer (NK) cell-based therapies have been increasingly studied with
their advantages of less treatment-related toxicity and lack of HLA restriction. Induced …

Differentiation of natural killer cells from induced pluripotent stem cells under defined, serum-and feeder-free conditions

KB Lupo, JI Moon, AM Chambers, S Matosevic - Cytotherapy, 2021 - Elsevier
Background aims Traditionally, natural killer (NK) cells are sourced from the peripheral
blood of donors―a laborious and highly donor-specific process. Processes for generating …