Biotransformation in the zebrafish embryo–temporal gene transcription changes of cytochrome P450 enzymes and internal exposure dynamics of the AhR binding …

A Kühnert, C Vogs, B Seiwert, S Aulhorn… - Environmental …, 2017 - Elsevier
Not much is known about the biotransformation capability of zebrafish (Danio rerio)
embryos. For understanding possible toxicity differences to adult fish, it might be crucial to …

Benzo [a] pyrene and 2, 3-benzofuran induce divergent temporal patterns of AhR-regulated responses in zebrafish embryos (Danio rerio)

H Meyer-Alert, M Larsson, H Hollert… - … and Environmental Safety, 2019 - Elsevier
Biotests like the fish embryo toxicity test have become increasingly popular in risk
assessment and evaluation of chemicals found in the environment. The large range of …

Time-dependent expression and activity of cytochrome P450 1s in early life-stages of the zebrafish (Danio rerio)

J Bräunig, S Schiwy, O Broedel, Y Müller… - … Science and Pollution …, 2015 - Springer
Zebrafish embryos are being increasingly used as model organisms for the assessment of
single substances and complex environmental samples for regulatory purposes. Thus, it is …

A temporal high-resolution investigation of the Ah-receptor pathway during early development of zebrafish (Danio rerio)

H Meyer-Alert, K Ladermann, M Larsson, S Schiwy… - Aquatic toxicology, 2018 - Elsevier
In order to contribute to a comprehensive understanding of the regulating mechanisms of the
aryl-hydrocarbon-receptor (AHR) in zebrafish embryos, we aimed to elucidate the interaction …

Cytochrome P450-dependent biotransformation capacities in embryonic, juvenile and adult stages of zebrafish (Danio rerio)—a state-of-the-art review

AK Loerracher, T Braunbeck - Archives of Toxicology, 2021 - Springer
Given the strong trend to implement zebrafish (Danio rerio) embryos as translational model
not only in ecotoxicological, but also toxicological testing strategies, there is an increasing …

Spatio-temporal development of CYP1 activity in early life-stages of zebrafish (Danio rerio)

JC Otte, AD Schmidt, H Hollert, T Braunbeck - Aquatic Toxicology, 2010 - Elsevier
Endpoints of planar halogenated aromatic hydrocarbon (pHAH) and polycyclic aromatic
hydrocarbon (PAH) toxicity are mediated via activation of the aryl hydrocarbon receptor …

In vitro CYP1A activity in the zebrafish: temporal but low metabolite levels during organogenesis and lack of gender differences in the adult stage

M Saad, E Verbueken, C Pype, C Casteleyn… - Reproductive …, 2016 - Elsevier
The zebrafish (Danio rerio) is increasingly used as a screening model for acute, chronic and
developmental toxicity. More specifically, the embryo is currently investigated as a …

From mRNA expression of drug disposition genes to in vivo assessment of CYP-mediated biotransformation during zebrafish embryonic and larval development

E Verbueken, C Bars, JS Ball, J Periz-Stanacev… - International journal of …, 2018 - mdpi.com
The zebrafish (Danio rerio) embryo is currently explored as an alternative for developmental
toxicity testing. As maternal metabolism is lacking in this model, knowledge of the disposition …

In vitro biotransformation of two human CYP3A probe substrates and their inhibition during early zebrafish development

E Verbueken, D Alsop, MA Saad, C Pype… - International journal of …, 2017 - mdpi.com
At present, the zebrafish embryo is increasingly used as an alternative animal model to
screen for developmental toxicity after exposure to xenobiotics. Since zebrafish embryos …

Detection of exposure effects of mixtures of heavy polycyclic aromatic hydrocarbons in zebrafish embryos

A Barranco, L Escudero… - Journal of Applied …, 2017 - Wiley Online Library
In this study we evaluated the exposure effects of mixtures of five polycyclic aromatic
hydrocarbons (PAHs); namely, benzo [a] anthracene, benzo [a] pyrene, benzo [b] …