Biotransformation in the zebrafish embryo–temporal gene transcription changes of cytochrome P450 enzymes and internal exposure dynamics of the AhR binding …
A Kühnert, C Vogs, B Seiwert, S Aulhorn… - Environmental …, 2017 - Elsevier
Not much is known about the biotransformation capability of zebrafish (Danio rerio)
embryos. For understanding possible toxicity differences to adult fish, it might be crucial to …
embryos. For understanding possible toxicity differences to adult fish, it might be crucial to …
Benzo [a] pyrene and 2, 3-benzofuran induce divergent temporal patterns of AhR-regulated responses in zebrafish embryos (Danio rerio)
H Meyer-Alert, M Larsson, H Hollert… - … and Environmental Safety, 2019 - Elsevier
Biotests like the fish embryo toxicity test have become increasingly popular in risk
assessment and evaluation of chemicals found in the environment. The large range of …
assessment and evaluation of chemicals found in the environment. The large range of …
Time-dependent expression and activity of cytochrome P450 1s in early life-stages of the zebrafish (Danio rerio)
Zebrafish embryos are being increasingly used as model organisms for the assessment of
single substances and complex environmental samples for regulatory purposes. Thus, it is …
single substances and complex environmental samples for regulatory purposes. Thus, it is …
A temporal high-resolution investigation of the Ah-receptor pathway during early development of zebrafish (Danio rerio)
H Meyer-Alert, K Ladermann, M Larsson, S Schiwy… - Aquatic toxicology, 2018 - Elsevier
In order to contribute to a comprehensive understanding of the regulating mechanisms of the
aryl-hydrocarbon-receptor (AHR) in zebrafish embryos, we aimed to elucidate the interaction …
aryl-hydrocarbon-receptor (AHR) in zebrafish embryos, we aimed to elucidate the interaction …
Cytochrome P450-dependent biotransformation capacities in embryonic, juvenile and adult stages of zebrafish (Danio rerio)—a state-of-the-art review
AK Loerracher, T Braunbeck - Archives of Toxicology, 2021 - Springer
Given the strong trend to implement zebrafish (Danio rerio) embryos as translational model
not only in ecotoxicological, but also toxicological testing strategies, there is an increasing …
not only in ecotoxicological, but also toxicological testing strategies, there is an increasing …
Spatio-temporal development of CYP1 activity in early life-stages of zebrafish (Danio rerio)
JC Otte, AD Schmidt, H Hollert, T Braunbeck - Aquatic Toxicology, 2010 - Elsevier
Endpoints of planar halogenated aromatic hydrocarbon (pHAH) and polycyclic aromatic
hydrocarbon (PAH) toxicity are mediated via activation of the aryl hydrocarbon receptor …
hydrocarbon (PAH) toxicity are mediated via activation of the aryl hydrocarbon receptor …
In vitro CYP1A activity in the zebrafish: temporal but low metabolite levels during organogenesis and lack of gender differences in the adult stage
M Saad, E Verbueken, C Pype, C Casteleyn… - Reproductive …, 2016 - Elsevier
The zebrafish (Danio rerio) is increasingly used as a screening model for acute, chronic and
developmental toxicity. More specifically, the embryo is currently investigated as a …
developmental toxicity. More specifically, the embryo is currently investigated as a …
From mRNA expression of drug disposition genes to in vivo assessment of CYP-mediated biotransformation during zebrafish embryonic and larval development
E Verbueken, C Bars, JS Ball, J Periz-Stanacev… - International journal of …, 2018 - mdpi.com
The zebrafish (Danio rerio) embryo is currently explored as an alternative for developmental
toxicity testing. As maternal metabolism is lacking in this model, knowledge of the disposition …
toxicity testing. As maternal metabolism is lacking in this model, knowledge of the disposition …
In vitro biotransformation of two human CYP3A probe substrates and their inhibition during early zebrafish development
E Verbueken, D Alsop, MA Saad, C Pype… - International journal of …, 2017 - mdpi.com
At present, the zebrafish embryo is increasingly used as an alternative animal model to
screen for developmental toxicity after exposure to xenobiotics. Since zebrafish embryos …
screen for developmental toxicity after exposure to xenobiotics. Since zebrafish embryos …
Detection of exposure effects of mixtures of heavy polycyclic aromatic hydrocarbons in zebrafish embryos
A Barranco, L Escudero… - Journal of Applied …, 2017 - Wiley Online Library
In this study we evaluated the exposure effects of mixtures of five polycyclic aromatic
hydrocarbons (PAHs); namely, benzo [a] anthracene, benzo [a] pyrene, benzo [b] …
hydrocarbons (PAHs); namely, benzo [a] anthracene, benzo [a] pyrene, benzo [b] …
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