DNA methylation plays important roles in determining cellular identity, disease, and
environmental responses, but little is known about the mechanisms that drive methylation …

DNA methylation is the most widely-studied epigenetic modification, playing a critical role in
the regulation of gene expression. Dysregulation of DNA methylation is implicated in the …

DNA methylation is an essential epigenetic mark, strongly associated with gene expression
regulation. Aberrant DNA methylation patterns underlie various diseases and efforts to …

Mammalian DNA methylation is a critical epigenetic mechanism orchestrating gene
expression networks in many biological processes. However, investigation of the functions …

DNA methylation abnormalities are regarded as critical event for cancer initiation and
development. Tumor-associated genes encompassing aberrant DNA methylation alterations …

DNA methylation plays a pivotal role in various biological processes and is highly related to
multiple diseases. The exact functions of DNA methylation are still puzzling due to its …

Background Cytosine DNA methylation is widely described as a transcriptional repressive
mark with the capacity to silence promoters. Epigenome engineering techniques enable …

Reversing DNA methylation abnormalities and associated gene silencing, through inhibiting
DNA methyltransferases (DNMTs) is an important potential cancer therapy paradigm …

DNA methylation plays a key role in regulating eukaryotic gene expression. Although
mitotically heritable and stable over time, patterns of DNA methylation frequently change in …

DNA methylation is one of the most important heritable epigenetic modifications of the
genome and is involved in the regulation of many cellular processes. Aberrant DNA …