We show that the MutY protein competes with the MutS-dependent mismatch repair system
to process at least some A· C mispairs in vivo, converting them to G· C pairs. In the presence …

In Escherichia coli and related bacteria, the very-short-patch (VSP) repair pathway uses an
endonuclease, Vsr, to correct T· G mismatches that result from the deamination of 5 …

The MutS protein is part of thedam-directed MutHLS mismatch repair pathway inEscherichia
coli. We have constructed deletion derivatives in the mutS gene, which retain the P-loop …

The mismatch repair pathway in Escherichia coli has been extensively studied in vitro as
well as in vivo. The molecular mechanisms by which nucleotide cofactors regulate the whole …

We have used direct selections to generate large numbers of mutants of Escherichia coli
defective in the mismatch repair system and have screened these to identify mutants with …

We have used the recently determined crystal structures of Escherichia coli (E. coli) MutS,
MutL and MutH to guide construction of 47 amino-acid substitutions in these proteins and …

MutS and MutL are both required to activate downstream events in DNA mismatch repair.
We examined the rate of dissociation of MutS from a mismatch using linear heteroduplex …

An Escherichia coli K-12 strain was constructed with a chromosomal deletion (mutS Δ 800)
in the mutS gene that produced the removal of the C-terminal 53 amino acids which are not …

DNA mismatch repair in Escherichia coli has been shown to be involved in two distinct
processes: mutation avoidance, which removes potential mutations arising as replication …

Repair of heteroduplex DNA containing an A/G mismatch in a mutL background requires the
Escherichia coli mutY gene function. The mutY-dependent in vitro repair of A/G mismatches …