Heterodimeric complexes of MutS-and MutL-related proteins were identified from studies of
DNA mismatch repair (MMR) and have been implicated in processing of recombination …

In model DNA, A pairs with T, and C with G. However, in vivo, the complementarity of the
DNA strands may be disrupted by errors in DNA replication, biochemical modification of …

To investigate the mechanisms of spontaneous mutation in the Escherichia coli mutD5
mutator strain, 502 mutations generated in this strain in the N-terminal part of the lacI gene …

Ensuring high-fidelity DNA replication is essential for maintaining genome stability in
organisms from Escherichia coli to humans. This task requires an intricate network of cellular …

Misalignment of repeated sequences during DNA replication can lead to deletions or
duplications in genomic DNA. In Escherichia coli, such genetic rearrangements can occur at …

DNA mismatch repair (MMR) is initiated when the MutS protein recognizes damaged DNA.
Crystal structures of MutS bound to mispaired and unpaired DNA show how MutS …

Homologs of the Escherichia coli (mutL, S and uvrD) and Streptococcus pneumoniae (hexA,
B) genes involved in mismatch repair are known in several distantly related organisms …

We have refined a series of isomorphous crystal structures of the Escherichia coli DNA
mismatch repair enzyme MutS in complex with G: T, A: A, C: A and G: G mismatches and …

Some of the molecular aspects of methyl-directed mismatch repair in E. coli have been
characterized. These include: mismatch recognition by mutS protein in which different …

Interaction between MutS and the replication factor β clamp has been extensively studied in
a Mismatch Repair context; however, its functional consequences are not well understood …