Due to large surface area, tunable pore size, easy surface manipulation, and low-toxicity
mesoporous silica nanoparticles (MSNs) may act as a suitable vector for gene delivery. In …

Mesoporous silica nanoparticles (MSNs) with large surface area, tunable pore size, and low
toxicity can act as suitable vehicles for drug and gene delivery. An MSN/DNA/PEI complex …

Gene therapy is a promising strategy for treatment of genetically caused diseases.
Successful gene delivery requires an efficient carrier to transfer the desired gene into host …

Purpose To prepare mesoporous silica-based delivery systems capable of simultaneous
delivery of drugs and nucleic acids. Methods The surface of mesoporous silica nanoparticles …

Organic–inorganic nanohybrids have been studied for their use as non-viral transfection
agents. The purpose of this study was to examine the ability of mesoporous silica …

Effective gene delivery system plays an importmant role in the gene therapy. Mesoporous
silica nanoparticle (MSN) has become one potential gene delivery vector because of its high …

Mesoporous silica nanoparticles (MSN) were functionalized with aminopropyltriethoxysilane
(MSN-NH 2) then l-histidine (MSN-His) for pDNA delivery in cells and in vivo. The …

Mesoporous silica nanoparticles have been synthesized and functionalized with four
different types of molecules containing amino groups, ie, with primary amines only, with …

Among various nanoparticles, the silica nanoparticle (SiNP) is an attractive candidate as a
gene delivery carrier due to advantages such as availability in porous forms for …

Cancer remains a major global health challenge. Traditional chemotherapy often results in
side effects and drug resistance, necessitating the development of alternative treatment …