Toinvestigate the relationship between the amount of amiodarone and the major metabolite
N-desethylamiodarone found in the lung with the development of toxicity, Fischer 344 and …

Toinvestigate the hypotheses that amiodarone-induced pulmonary inflammation may be
related to direct drug toxicity, groups of 10or more Wistar rats were fed amiodarone by …

Treatment of humans with the antiarrhythmic drug amiodarone can cause pulmonary
pathology and toxicity. The disorder is associated with the accumulation of phospholipid …

Amiodarone is a clinically effective antiarrhythmic drug shown to cause lung damage in
humans and animals. While the mechanism of this pulmonary toxicity is unknown, it may be …

Pulmonary and hepatotoxicity arc the two major side effects of chronic amiodarone therapy.
We studied the accumulation of amiodarone and its principal metabolite …

Amiodarone (AD) has been shown to produce a transient pulmonary fibrosis in hamsters
after intratracheal (it) instillation. The goal of this study was to examine bronchoalveolar …

A rat model of amiodarone-induced pulmonary toxicity is described. The rats were fed, by
gavage, 175 mg/kg/day of amiodarone hydrochloride suspended in methyl cellulose …

Conclusions Since the discovery of amiodarone over 30 years ago, the mechanisms
underlying serious adverse effects remain to be resolved and still limit drug usefulness …

Associated with amiodarone use is pneumonitis which may progress to life-threatening
pulmonary fibrosis. Desethylamiodarone, a metabolite, whose role in the etiology of …

Administration of the antiarrhythmic drug amiodarone to humans or animals may result in
lung damage. Amiodarone is metabolized to desethylamiodarone and other minor …