Efficient intracellular drug delivery and target specificity are often hampered by the presence
of biological barriers. Thus, compounds that efficiently cross cell membranes are the key to …

An important hurdle for the intracellular delivery of large cargo is the cellular membrane,
which protects the cell from exogenous substances. Cell-penetrating peptides (CPPs) can …

The intrinsic property of cell-penetrating peptides (CPPs) to deliver therapeutic molecules
(nucleic acids, drugs, imaging agents) to cells and tissues in a nontoxic manner has …

Unique characteristics, such as nontoxicity and rapid cellular internalization, allow the cell-
penetrating peptides (CPPs) to transport hydrophilic macromolecules into cells, thus …

During the three decades of cell-penetrating peptides era the superfamily of CPPs has
rapidly expanded, and the quest for new sequences continues. CPPs have been well …

Cell-penetrating peptides (CPPs) provide promising tools for the cellular delivery of
molecular cargos ranging in size from small molecules and peptides to proteins and …

With more than ten new FDA approvals since 2001, peptides are emerging as an important
therapeutic alternative to small molecules. However, unlike small molecules, peptides on the …

The selective permeability of the plasma membrane prohibits most exogenous agents from
gaining cellular access. Since many therapeutics and reporter molecules must be …

The selective infiltration of cell membranes and tissue barriers often blocks the entry of most
active molecules. This natural defense mechanism prevents the invasion of exogenous …

The current landscapes of novel therapeutic approaches rely mostly on gene‐targeted
technologies, enabling to fight rare genomic diseases, from infections to cancer and …