Erythroid differentiation is controlled by the dynamic exchange of GATA family transcription
factors. During early erythroid maturation, high GATA2 levels activate progenitor genes such …

Strict regulations of the Gata1 and Gata2 genes are critical for proper lineage commitment
and development of erythroid cells. It has been shown in transgenic mouse analyses that cis …

Transcription factor GATA-1 is required for erythropoiesis, yet its full actions are unknown.
We performed transcriptome analysis of G1E-ER4 cells, a GATA-1–null erythroblast line that …

The X-linked blood transcription factor GATA1 is required for the survival and maturation of
erythroid cells. Loss of Gata1 causes profound anemia and related mid-gestation lethality in …

Transcription factor GATA 2 is highly expressed in hematopoietic stem cells and progenitors,
whereas its expression declines after erythroid commitment of progenitors. In contrast, the …

The hematopoietic GATA factors GATA-1 and GATA-2, which have distinct and overlapping
roles to regulate blood cell development, are reciprocally expressed during erythropoiesis …

Mutations in GATA1, which lead to expression of the GATA1s isoform that lacks the GATA1
N terminus, are seen in patients with Diamond-Blackfan anemia (DBA). In our efforts to …

GATA transcription factor family members GATA1 and GATA2 play crucial roles in the
regulation of lineage-restricted genes during erythroid differentiation. GATA1 is …

GATA‐1 is essential for the generation of the erythroid, megakaryocytic, eosinophilic and
mast cell lineages. It acts as an activator and repressor of different target genes, for example …

Interplay among GATA transcription factors is an important determinant of cell fate during
hematopoiesis. Although GATA-2 regulates hematopoietic stem cell function, mechanisms …