Prostate cancer is one of the most frequent cancers in males in Western industrialized
countries. Its course is highly variable, from indolent to highly lethal. Genetic changes vary …

Epigenetic alterations, including changes in DNA methylation, histone modifications and
nucleosome remodeling, result in abnormal gene expression patterns that contribute to …

Epigenetic mechanisms permit the stable inheritance of cellular properties without changes
in DNA sequence or amount. In prostate carcinoma, epigenetic mechanisms are essential …

The initiation of prostate cancer has been long associated with DNA copy-number
alterations, the loss of specific chromosomal regions and gene fusions, and driver mutations …

The androgen receptor (AR) is a transcription factor that drives the differentiation of prostate
epithelium by regulating the expression of several hundred genes. Conversely, AR also …

Prostate cancer is a commonly diagnosed cancer in men and a leading cause of cancer
deaths. Whilst the underlying mechanisms leading to prostate cancer are still to be …

Epigenetics is the main mechanism that controls transcription of specific genes with no
changes in the underlying DNA sequences. Epigenetic alterations lead to abnormal gene …

Simple Summary Chromatin and epigenetic alterations in cancer are responsible for a wide
range of transcriptional changes that link DNA mutations to tumor phenotype. In this review …

Abstract Purpose of Review An important number of newly identified molecular alterations in
prostate cancer affect gene encoding master regulators of chromatin biology epigenetic …

Studies on the genetic basis of prostate cancer (PCa) have lead to mixed results with the
only consensus being that PCa is a complex disease. Our goal was to gain insight into …