The molecular mechanisms underlying the development and progression of prostate cancer
are poorly understood. Epidemiological studies have suggested that 5-10% of all prostate …

Prostate cancer (PC) is the most commonly diagnosed nonskin malignancy and the second
most common cause of cancer death among men in the United States. Epigenetics is the …

Epigenetic mechanisms may be the main driving force for critical changes in gene
expression that are responsible for progression of prostate cancers. The three most …

Prostate cancer is one of the most commonly diagnosed and potentially devastating cancers
in men, throughout the world. However, the clinical manifestation of this disease varies …

Background With continuous progress over the past few decades in understanding
diagnosis, treatment, and genetics, much has been learned about the prostate cancer …

Epigenetic changes improve the specificity and sensitivity of PCa diagnosis and have the
potential to help determine clinical prognosis. Additional studies will not only provide new …

During cancer development and progression, tumor cells undergo abnormal epigenetic
modifications, including DNA methylation, histone deacetylation and nucleosome …

The androgen receptor (AR) is commonly known as a key transcription factor in prostate
cancer development, progression and therapy resistance. Genome-wide chromatin …

Prostate cancer is the sixth most common cancer in the world and the third leading cause of
cancer in men. The increase in the understanding of prostate carcinogenesis over the past …

Prostate cancer (PCa) is the most prevalent urological cancer that affects aging men in
South Africa, and mechanisms underlying prostate tumorigenesis remain elusive. Research …