Prostate cancer (PCa) is the most prevalent urological cancer that affects aging men in
South Africa, and mechanisms underlying prostate tumorigenesis remain elusive. Research …

Although prostate cancer is the most common malignancy to affect men in the Western
world, the molecular mechanisms underlying its development and progression remain …

PURPOSE: Prostate cancer research has focused significant attention on the mutation,
deletion or amplification of the DNA base sequence that encodes critical growth or …

There is increasing evidence that DNA methylation is a critical source of gene regulation. In
addition, interindividual differences in DNA methylation status in cancer related genes are …

Prostate cancer co-opts a unique set of cellular pathways in its initiation and progression.
The heterogeneity of prostate cancers is evident at earlier stages, and has led to rigorous …

Tumor evolution is based on the ability to constantly mutate and activate different pathways
under the selective pressure of targeted therapies. Epigenetic alterations including those of …

This chapter will summarize novel understandings of the early molecular events in prostatic
carcinogenesis that may underlie both the genetic and clinical heterogeneity. Areas covered …

Epigenetic mechanisms including DNA methylation and histone deacetylation are thought to
play important roles in gene transcriptional inactivation. Heterogenous expression of …

Prostatic adenocarcinoma is extremely common in Western nations, representing the
second leading cause of cancer death in American men. The recent application of …

The identification of genes that contribute to the biological basis for clinical heterogeneity
and progression of prostate cancer is critical to accurate classification and appropriate …