Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …

The molecular/genetic era has seen the discovery of a staggering number of molecules
implicated in pain mechanisms [18],[35],[61],[69],[96],[133],[150],[202],[224]. This has …

Nociception provides a means of neural feedback that allows the central nervous system
(CNS) to detect and avoid noxious and potentially damaging stimuli in both active and …

There are two basic categories of pain: physiological pain, which serves an important
protective function, and pathological pain, which can have a major negative impact on …

Specialized peripheral sensory neurons known as nociceptors alert us to potentially
damaging stimuli at the skin by detecting extremes in temperature and pressure and injury …

Pain is a complex multidimensional concept that facilitates the initiation of the signaling
cascade in response to any noxious stimuli. Action potential generation in the peripheral …

Advances in the characterization of pain signaling in recent years indicate that distinct
neurophysiological and neurochemical mechanisms contribute to pain arising from injury to …

During evolution, living organisms develop a specialized apparatus called nociceptors to
sense their environment and avoid hazardous situations. Intense stimulation of high …

Pathological pain, consisting of tissue injury-induced inflammatory and nerve injury-induced
neuropathic pain, is an expression of neuronal plasticity. One component of this is that the …

Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …