Protein kinases play a predominant regulatory role in nearly every aspect of cell biology and
they can modify the function of a protein in almost every conceivable way. Protein …

Protein kinases regulate nearly all aspects of cell life, and alterations in their expression, or
mutations in their genes, cause cancer and other diseases. Here, we review the remarkable …

The FDA approval of imatinib in 2001 was a breakthrough in molecularly targeted cancer
therapy and heralded the emergence of kinase inhibitors as a key drug class in the oncology …

Protein kinases are fascinating biological catalysts with a rapidly expanding knowledge
base, a growing appreciation in cell regulatory control, and an ascendant role in successful …

There are over 500 human kinases ranging from very well-studied to almost completely
ignored. Kinases are tractable and implicated in many diseases, making them ideal targets …

The understanding of the pathophysiology of a large number of cancer types provides a
strategy to target cancer cells with minimal effect on normal cells. Protein phosphorylation …

Kinase inhibitor research is a comparatively recent branch of medicinal chemistry and
pharmacology and the first small‐molecule kinase inhibitor, imatinib, was approved for …

The development and therapeutic potential of protein kinase inhibitors r Page 1 459 The
development and therapeutic potential of protein kinase inhibitors Philip Cohen A number of …

Kinases are highly regulated enzymes with diverse mechanisms controlling their catalytic
output. Over time, chemical discovery efforts for kinases have produced ATP-competitive …

The success of the tyrosine kinase imatinib inhibitor (Gleevec, STI571) in treating chronic
myeloid leukemia as well as other selected cancers has greatly increased optimism for the …