Differential modulation of IL-4, IL-10, IL-17, and IFN-γ production mediated by IgG from Human T-lymphotropic virus-1 (HTLV-1) infected patients on healthy peripheral …

NR Machado, BO Fagundes, LA Fernandes… - Frontiers in …, 2023 - frontiersin.org
Human T-lymphotropic virus 1 (HTLV-1) infected individuals remain as asymptomatic
carriers (ACs) or can develop the chronic neurological disorder HTLV-1-associated …

Imbalanced IL10/TGF-β production by regulatory T-lymphocytes in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis

LL Gois, B Ribeiro-Soares, CG Regis-Silva… - BMC Infectious …, 2024 - Springer
Background Human T-cell lymphotropic virus type 1 (HTLV-1), also denominated Human T-
cell leukemia virus-1, induces immune activation and secretion of proinflammatory …

IL-10 produced by CD4+ and CD8+ T cells emerge as a putative immunoregulatory mechanism to counterbalance the monocyte-derived TNF-α and guarantee …

GEA Brito-Melo, V Peruhype-Magalhaes… - Clinical & …, 2007 - academic.oup.com
Although it is believed widely that distinct patterns of the host immune response are
associated with the outcome of chronic human T cell lymphotropic virus type 1 (HTLV-I) …

Abnormally High Levels of Virus-Infected IFN-γ+CCR4+CD4+CD25+ T Cells in a Retrovirus-Associated Neuroinflammatory Disorder

Y Yamano, N Araya, T Sato, A Utsunomiya, K Azakami… - PloS one, 2009 - journals.plos.org
Background Human T-lymphotropic virus type 1 (HTLV-1) is a human retrovirus associated
with both HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), which is a …

High IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus type 1-infected clones are associated with human T-cell …

OM Espíndola, LC Oliveira, P Ferreira, ACCB Leite… - Intervirology, 2015 - karger.com
Background/Aims: Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that
causes a persistent infection, and only 0.5-5% of infected individuals will develop HTLV-1 …

Cytokine networks dysregulation during HTLV-1 infection and associated diseases

N Futsch, G Prates, R Mahieux, J Casseb, H Dutartre - Viruses, 2018 - mdpi.com
Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of a neural chronic
inflammation, called HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) …

IL-10-mediated signals act as a switch for lymphoproliferation in Human T-cell leukemia virus type-1 infection by activating the STAT3 and IRF4 pathways

L Sawada, Y Nagano, A Hasegawa, H Kanai… - PLoS …, 2017 - journals.plos.org
Human T-cell leukemia virus type-1 (HTLV-1) causes two distinct diseases, adult T-cell
leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis …

Modulation of T cell responses in HTLV-1 carriers and in patients with myelopathy associated with HTLV-1

SB Santos, AF Porto, AL Muniz, T Luna… - …, 2007 - karger.com
Objective: Human T lymphotropic virus-type 1 (HTLV-1) activates the immune system
leading to a persistent and exacerbated T-cell response with increased production of IFN-γ …

Human T lymphotropic virus type 1 (HTLV-1) proviral load induces activation of T-lymphocytes in asymptomatic carriers

R Coutinho, MFR Grassi, AB Korngold… - BMC Infectious …, 2014 - Springer
Background High HTLV-1 proviral load (PVL) is mainly found in infected individuals with
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). However one third …

T helper type 9 cell response and its role in the neurological clinic of patients with Human T-lymphotropic virus 1

RSR Júnior, JAN Gomes, GA da Silva Dias, S Fujihara… - Immunobiology, 2023 - Elsevier
Human T-lymphotropic virus 1 (HTLV-1) affects 5–10 million individuals worldwide. Most of
those infected with this virus remain asymptomatic; however, 0.25%–4% of individuals …