Both Alzheimer's disease (AD) and almost every second case of frontotemporal lobar
degeneration (FTLD) are characterized by the deposition of hyperphosphorylated forms of …

In 1975, tau protein was isolated as a microtubule-associated factor from the porcine brain.
In the previous year, a paired helical filament (PHF) protein had been identified in …

The abnormal deposition of proteins in and around neurons is a common pathological
feature of many neurodegenerative diseases. Among these pathological proteins, the …

Both Alzheimer′ s disease (AD) and frontotemporal dementia (FTD) are characterized by
the deposition of hyperphosphorylated forms of the microtubule‐associated protein tau in …

The pathology associated with tau protein, tauopathy, has been recently analyzed in
different disorders, leading to the suggestion that intracellular and extracellular tau may itself …

Frontotemporal lobar degeneration (FTLD) has been associated with toxic intracellular
aggregates of hyperphosphorylated tau (FTLD‐tau). Moreover, genetic studies identified …

Most dementing disorders result from a degenerating process named tauopathy. Alzheimer
disease is the most frequent one, but only one among the large spectrum of tau-related …

Tau, a microtubule-associated protein, is the main component of the intracellular filamentous
inclusions that are involved in neurodegenerative diseases known as tauopathies, including …

Since the identification of tau as the main component of neurofibrillary tangles in Alzheimer's
disease and related tauopathies, and the discovery that mutations in the tau gene cause …

Tau is an evolutionary conserved protein that promotes the assembly and stabilization of
microtubules in neuronal axons. Complex patterns of posttranslational modifications (PTMs) …