ARMING INDUCED PLURIPOTENT STEM CELLS WITH A SYNTHETIC RECEPTOR PROMOTES MASSIVE PRODUCTION OF IMMUNE EFFECTOR CELLS …
A Yingst, D Vereide, D Jarrell, R Koning, C Arnold… - Cytotherapy, 2024 - Elsevier
Background & Aim Induced pluripotent stem cells (iPSCs) are an ideal starting material for
cell-based therapies, however, manufacturing therapeutic cells from iPSCs has often been …
cell-based therapies, however, manufacturing therapeutic cells from iPSCs has often been …
Generation of synthetic cytokine receptor-induced cytotoxic innate lymphocytes (iCILs) from iPSCs as off-the-shelf cancer therapeutics
S O'Hara, T Rowland, R Koning, D Vereide… - Cancer Research, 2022 - AACR
Off-the-shelf immune cell products derived from induced pluripotent stem cells (iPSC) have
the potential to address many of the current limitations of engineered autologous and …
the potential to address many of the current limitations of engineered autologous and …
[HTML][HTML] Immune Cell Generation from Human-Induced Pluripotent Stem Cells: Current Status and Challenges
YY Xiong, YW Zheng - 2023 - intechopen.com
The immune system plays a crucial role in recognizing and eliminating foreign antigens,
working in conjunction with other bodily systems to maintain the stability and physiological …
working in conjunction with other bodily systems to maintain the stability and physiological …
Derivation of transgene-free human induced pluripotent stem cells from human peripheral T cells in defined culture conditions
Recently, induced pluripotent stem cells (iPSCs) were established as promising cell sources
for revolutionary regenerative therapies. The initial culture system used for iPSC generation …
for revolutionary regenerative therapies. The initial culture system used for iPSC generation …
Engineered T cells from induced pluripotent stem cells: from research towards clinical implementation
R Netsrithong, L Garcia-Perez, M Themeli - Frontiers in immunology, 2024 - frontiersin.org
Induced pluripotent stem cell (iPSC)-derived T (iT) cells represent a groundbreaking frontier
in adoptive cell therapies with engineered T cells, poised to overcome pivotal limitations …
in adoptive cell therapies with engineered T cells, poised to overcome pivotal limitations …
Induced pluripotent stem cells–derived hematopoietic progenitors for cellular immunotherapies
Cellular therapies combined with genetic engineering technologies have emerged as
increasingly powerful tools for immunotherapies of cancers and viral infections including HIV …
increasingly powerful tools for immunotherapies of cancers and viral infections including HIV …
Induced pluripotent stem cell (iPSCs) and their application in immunotherapy
Z Jiang, Y Han, X Cao - Cellular & molecular immunology, 2014 - nature.com
The ever-improving technology to generate induced pluripotent stem cells (iPSCs) has
increased their potential use as novel candidates for disease modeling, drug screening …
increased their potential use as novel candidates for disease modeling, drug screening …
iPSC-BASED IMMUNOTHERAPY DIFFERENTIATION PLATFORM ENABLES FEEDER-FREE EXPANSION OF NK CELLS TO CLINICAL SCALE
D Terheyden-Keighley, B Hiller, A Gamerschlag… - Cytotherapy, 2024 - Elsevier
Background & Aim Human induced pluripotent stem cells (iPSCs) are emerging as a potent
starting material for allogeneic cell therapies. As a prerequisite, we have established a GMP …
starting material for allogeneic cell therapies. As a prerequisite, we have established a GMP …
Advances in adoptive cell therapy using induced pluripotent stem cell-derived T cells
R Netsrithong, M Wattanapanitch - Frontiers in immunology, 2021 - frontiersin.org
Adoptive cell therapy (ACT) using chimeric antigen receptor (CAR) T cells holds impressive
clinical outcomes especially in patients who are refractory to other kinds of therapy …
clinical outcomes especially in patients who are refractory to other kinds of therapy …
Do human leukocyte antigen-typed cellular therapeutics based on induced pluripotent stem cells make commercial sense?
CA Bravery - Stem cells and development, 2015 - liebertpub.com
The promise of off-the-shelf cellular therapeutics (CTPs) based on allogeneic induced
pluripotent stem cells (iPSCs) may be hindered by alloimmunity, leading many to suggest …
pluripotent stem cells (iPSCs) may be hindered by alloimmunity, leading many to suggest …