ARMING INDUCED PLURIPOTENT STEM CELLS WITH A SYNTHETIC RECEPTOR PROMOTES MASSIVE PRODUCTION OF IMMUNE EFFECTOR CELLS …

A Yingst, D Vereide, D Jarrell, R Koning, C Arnold… - Cytotherapy, 2024 - Elsevier
Background & Aim Induced pluripotent stem cells (iPSCs) are an ideal starting material for
cell-based therapies, however, manufacturing therapeutic cells from iPSCs has often been …

Generation of synthetic cytokine receptor-induced cytotoxic innate lymphocytes (iCILs) from iPSCs as off-the-shelf cancer therapeutics

S O'Hara, T Rowland, R Koning, D Vereide… - Cancer Research, 2022 - AACR
Off-the-shelf immune cell products derived from induced pluripotent stem cells (iPSC) have
the potential to address many of the current limitations of engineered autologous and …

[HTML][HTML] Immune Cell Generation from Human-Induced Pluripotent Stem Cells: Current Status and Challenges

YY Xiong, YW Zheng - 2023 - intechopen.com
The immune system plays a crucial role in recognizing and eliminating foreign antigens,
working in conjunction with other bodily systems to maintain the stability and physiological …

Derivation of transgene-free human induced pluripotent stem cells from human peripheral T cells in defined culture conditions

Y Kishino, T Seki, J Fujita, S Yuasa, S Tohyama… - PloS one, 2014 - journals.plos.org
Recently, induced pluripotent stem cells (iPSCs) were established as promising cell sources
for revolutionary regenerative therapies. The initial culture system used for iPSC generation …

Engineered T cells from induced pluripotent stem cells: from research towards clinical implementation

R Netsrithong, L Garcia-Perez, M Themeli - Frontiers in immunology, 2024 - frontiersin.org
Induced pluripotent stem cell (iPSC)-derived T (iT) cells represent a groundbreaking frontier
in adoptive cell therapies with engineered T cells, poised to overcome pivotal limitations …

Induced pluripotent stem cells–derived hematopoietic progenitors for cellular immunotherapies

I Slukvin, SS D'Souza, A Kumar - iPSC Derived Progenitors, 2022 - Elsevier
Cellular therapies combined with genetic engineering technologies have emerged as
increasingly powerful tools for immunotherapies of cancers and viral infections including HIV …

Induced pluripotent stem cell (iPSCs) and their application in immunotherapy

Z Jiang, Y Han, X Cao - Cellular & molecular immunology, 2014 - nature.com
The ever-improving technology to generate induced pluripotent stem cells (iPSCs) has
increased their potential use as novel candidates for disease modeling, drug screening …

iPSC-BASED IMMUNOTHERAPY DIFFERENTIATION PLATFORM ENABLES FEEDER-FREE EXPANSION OF NK CELLS TO CLINICAL SCALE

D Terheyden-Keighley, B Hiller, A Gamerschlag… - Cytotherapy, 2024 - Elsevier
Background & Aim Human induced pluripotent stem cells (iPSCs) are emerging as a potent
starting material for allogeneic cell therapies. As a prerequisite, we have established a GMP …

Advances in adoptive cell therapy using induced pluripotent stem cell-derived T cells

R Netsrithong, M Wattanapanitch - Frontiers in immunology, 2021 - frontiersin.org
Adoptive cell therapy (ACT) using chimeric antigen receptor (CAR) T cells holds impressive
clinical outcomes especially in patients who are refractory to other kinds of therapy …

Do human leukocyte antigen-typed cellular therapeutics based on induced pluripotent stem cells make commercial sense?

CA Bravery - Stem cells and development, 2015 - liebertpub.com
The promise of off-the-shelf cellular therapeutics (CTPs) based on allogeneic induced
pluripotent stem cells (iPSCs) may be hindered by alloimmunity, leading many to suggest …