In higher eukaryotes, the Retinoblastoma and E2F families of proteins control the
transcription of a large number of target genes. Here, we have mutated the second …

The retinoblastoma (RB) family of proteins regulate transcription. These proteins lack
intrinsic DNA-binding activity but are recruited to specific genomic locations through …

E2F transcription factors can activate or actively repress transcription of their target genes.
The role of active repression during normal development has not been analyzed in detail …

The E2F family of transcription factors are downstream effectors of the retinoblastoma
protein, pRB, pathway and are essential for the timely regulation of genes necessary for cell …

Across metazoans, cell cycle progression is regulated by E2F family transcription factors that
can function as either transcriptional activators or repressors. For decades, the Drosophila …

To determine which E2F/RB-family members are functionally important at E2F-dependent
promoters, we used RNA interference (RNAi) to selectively remove each component of the …

Retinoblastoma proteins are eukaryotic transcriptional corepressors that play central roles in
cell cycle control, among other functions. Although most metazoan genomes encode a …

The growth suppressive function of the retinoblastoma (pRB) tumor suppressor family is
largely attributed to its ability to negatively regulate the family of E2F transcriptional factors …

The transcription factor DRTF1/E2F is implicated in the control of cellular proliferation due to
its interaction with key regulators of cell cycle progression, such as the retinoblastoma …

The pRB (retinoblastoma protein) has a central role in the control of the G1–S phase
transition of the cell cycle that is mediated in part through the regulation of E2F transcription …