Abstract Models for studying the quantitative effects of RB protein in development and in
tumorigenesis have been constructed. By crossing transgenic mice carrying the human Rb …

Mutational inactivation of the retinoblastoma gene (RB) is an invariant feature of the
childhood eye cancer retinoblastoma and of tumor cells derived therefrom. In a previous …

Upon inactivation of both alleles of the retinoblastoma gene (RB), individuals develop the
intraocular eye tumor, retinoblastoma. The gene encodes a M r 110,000 phosphorylated …

Expression of the human retinoblastoma gene (RB1) in tumor cells defective of the gene in
many instances abrogates the growth of the cells. Here we have evaluated the …

Mutational inactivation of the retinoblastoma (RB) gene has been implicated in the genesis
of retinoblastoma, osteosarcoma, and other human tumors. Our strategy has been to …

A class of cellular genes in which loss-of-function mutations are tumorigenic has been
proposed. Such genes would normally act to suppress the cancer phenotype at the cellular …

The retinoblastoma susceptibility gene product functions to prevent neoplastic
transformation in a variety of cell types. Inactivation of the retinoblastoma gene (RB) is …

Introduction of the normal retinoblastoma gene (RB) into different tumor cells possessing
inactivated RB genes suppresses their tumorigenicity in nude mice. These results suggest …

We have transfected the osteosarcoma cell line Saos2 and the bladder carcinoma cell line
5637 with additional retinoblastoma (RB) expression plasmids. The RB-reconstituted Saos2 …

To assess biological roles of the retinoblastoma protein (RB), four independent transgenic
mouse lines expressing human RB with different deletions in the N-terminal region (RBΔN) …