The central nervous system (CNS) is immune privileged with access to leukocytes being
limited. In several neurological diseases, however, infiltration of immune cells from the …

Multiple sclerosis (MS) is a debilitating neurological disorder of the central nervous system
(CNS), characterized by activation and infiltration of leukocytes and dendritic cells into the …

Multiple sclerosis (MS) is an autoimmune and neurodegenerative disorder characterized by
chronic inflammation, demyelination, as well as axonal and neuronal loss in the central …

Multiple sclerosis is a chronic demyelinating inflammatory disease of the central nervous
system (CNS). As the tissue macrophage of the CNS, microglia have the potential to …

In this review, we address current concepts regarding the mechanisms of tissue damage that
lead to demyelination and oligodendrocyte loss in multiple sclerosis. Particular emphasis …

In multiple sclerosis and the experimental autoimmune encephalomyelitis (EAE) model, both
resident microglia and infiltrating macrophages contribute to demyelination as well as …

There are over 15 disease-modifying drugs that have been approved over the last 20 years
for the treatment of relapsing–remitting multiple sclerosis (MS), but there are limited …

In the human disorder multiple sclerosis (MS) and in the model experimental autoimmune
encephalomyelitis (EAE), macrophages predominate in demyelinated areas and their …

One of the characteristic features of microglia is their rapid activation in response to injury,
inflammation, neurodegeneration, infection, and brain tumors. This review focuses on the …

Microglia participate in all phases of the multiple sclerosis (MS) disease process. As
members of the innate immune system, these cells have evolved to respond to …