The growing burden of obesity-and aging-related diseases has hastened the search for
governing biological processes. Cellular senescence is a stress-induced state of stable …

Cellular senescence is a cell fate that occurs in response to numerous types of stress and
can promote tissue repair or drive inflammation and disruption of tissue homeostasis …

Cellular Senescence: The Villain of Metabolic Disease? - PMC Back to Top Skip to main content
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Aging is a natural but relentless process of physiological decline, leading to physical frailty,
reduced ability to respond to physical stresses (resilience) and, ultimately, organismal death …

Abstract Purpose of Review Obesity has increased worldwide recently and represents a
major global health challenge. This review focuses on the obesity-associated cellular …

With the ageing of the global population, interest is growing in the 'geroscience hypothesis',
which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the …

Much of the population is now faced with an enormous burden of age-associated chronic
diseases. Recent discoveries in geroscience indicate that healthspan in model organisms …

In the last decades the prevalence of obesity has increased dramatically, and the worldwide
epidemic of obesity and related metabolic diseases has contributed to an increased interest …

Senescent cells accumulate in fat with aging. We previously found genetic clearance of
senescent cells from progeroid INK-ATTAC mice prevents lipodystrophy. Here we show that …

Cellular senescence, a process that imposes permanent proliferative arrest on cells in
response to various stressors, has emerged as a potentially important contributor to aging …