Natural killer cells: the next wave in cancer immunotherapy

X Chen, L Jiang, X Liu - Frontiers in immunology, 2022 - frontiersin.org
Immunotherapies focusing on rejuvenating T cell activities, like PD-1/PD-L1 and CTLA-4
blockade, have unprecedentedly revolutionized the landscape of cancer treatment. Yet a …

Harnessing natural killer cell effector function against cancer

MD Blunt, SI Khakoo - Immunotherapy Advances, 2024 - academic.oup.com
Natural killer (NK) cells are cytotoxic innate lymphoid cells that participate in anti-tumour and
anti-viral immune responses. Their ability to rapidly destroy abnormal cells and to enhance …

Natural killer cells: the linchpin for successful cancer immunotherapy

KA Shaver, TJ Croom-Perez, AJ Copik - Frontiers in immunology, 2021 - frontiersin.org
Cancer immunotherapy is a highly successful and rapidly evolving treatment modality that
works by augmenting the body's own immune system. While various immune stimulation …

Natural killer cell-based cancer immunotherapies: from immune evasion to promising targeted cellular therapies

E Hofer, U Koehl - Frontiers in immunology, 2017 - frontiersin.org
Immunotherapies based on natural killer (NK) cells are among the most promising therapies
under development for the treatment of so far incurable forms of leukemia and other types of …

Natural killer cell-targeted immunotherapy for cancer

J Tang, Q Zhu, Z Li, J Yang, Y Lai - Current Stem Cell Research …, 2022 - ingentaconnect.com
Natural Killer (NK) cells were initially described in the early 1970s as major
histocompatibility complex unrestricted killers due to their ability to spontaneously kill certain …

Natural killer cells: a promising immunotherapy for cancer

J Chu, F Gao, M Yan, S Zhao, Z Yan, B Shi… - Journal of translational …, 2022 - Springer
As a promising alternative platform for cellular immunotherapy, natural killer cells (NK) have
recently gained attention as an important type of innate immune regulatory cell. NK cells can …

Killers 2.0: NK cell therapies at the forefront of cancer control

JJ Hodgins, ST Khan, MM Park… - The Journal of …, 2019 - Am Soc Clin Investig
Natural killer (NK) cells are innate cytotoxic lymphocytes involved in the surveillance and
elimination of cancer. As we have learned more and more about the mechanisms NK cells …

[HTML][HTML] Cancer immunotherapy based on natural killer cells: current progress and new opportunities

W Hu, G Wang, D Huang, M Sui, Y Xu - Frontiers in immunology, 2019 - frontiersin.org
Cancer immunotherapy has been firmly established as a new milestone for cancer therapy,
with the development of multiple immune cells as therapeutic tools. Natural killer (NK) cells …

Natural killer cells in antitumour adoptive cell immunotherapy

TJ Laskowski, A Biederstädt, K Rezvani - Nature Reviews Cancer, 2022 - nature.com
Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with
intrinsic abilities to identify and eliminate virally infected cells and tumour cells. Possessing …

The application of natural killer cell immunotherapy for the treatment of cancer

K Rezvani, RH Rouce - Frontiers in immunology, 2015 - frontiersin.org
Natural killer (NK) cells are essential components of the innate immune system and play a
critical role in host immunity against cancer. Recent progress in our understanding of NK cell …