Gases in sepsis: novel mediators and therapeutic targets

Z Zhu, S Chambers, Y Zeng, M Bhatia - International Journal of Molecular …, 2022 - mdpi.com
Sepsis, a potentially lethal condition resulting from failure to control the initial infection, is
associated with a dysregulated host defense response to pathogens and their toxins. Sepsis …

Gaseous mediators in resolution of inflammation

JL Wallace, A Ianaro, KL Flannigan, G Cirino - Seminars in immunology, 2015 - Elsevier
There are numerous gaseous substances that can act as signaling molecules, but the best
characterized of these are nitric oxide, hydrogen sulfide and carbon monoxide. Each has …

Inflammatory mediators in sepsis: cytokines, chemokines, adhesion molecules and gases

R Devi Ramnath, S Weing, M He, J Sun… - Journal of Organ …, 2006 - Taylor & Francis
Sepsis is a systemic inflammatory response syndrome in response to severe infection. An
overwhelming systemic response brought about by the release of various inflammatory …

Subtle interplay of endogenous bioactive gases (NO, CO and H2S) in inflammation

HO Pae, YC Lee, EK Jo, HT Chung - Archives of pharmacal research, 2009 - Springer
Nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H 2 S) constitute a unique
class of mediators which play important roles in maintaining the homeostasis of biological …

Emergent role of gasotransmitters in ischemia-reperfusion injury

BF Moody, JW Calvert - Medical gas research, 2011 - Springer
Nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H 2 S) are lipid-soluble,
endogenously produced gaseous messenger molecules collectively known as …

Hydrogen sulfide and nitric oxide interactions in inflammation

MLL Faro, B Fox, JL Whatmore, PG Winyard… - Nitric oxide, 2014 - Elsevier
Together with carbon monoxide (CO), nitric oxide (radical dot NO) and hydrogen sulfide (H 2
S) form a group of physiologically important gaseous transmitters, sometimes referred to as …

Clinical applications for gasotransmitters in the cardiovascular system: are we there yet?

E Arrigo, S Comità, P Pagliaro, C Penna… - International Journal of …, 2023 - mdpi.com
Ischemia is the underlying mechanism in a wide variety of acute and persistent pathologies.
As such, understanding the fine intracellular events occurring during (and after) the …

Carbon monoxide in the treatment of sepsis

K Nakahira, AMK Choi - American Journal of Physiology …, 2015 - journals.physiology.org
Carbon monoxide (CO), a low-molecular-weight gas, is endogenously produced in the body
as a product of heme degradation catalyzed by heme oxygenase (HO) enzymes. As the …

Role of gasotransmitters in inflammatory edema

SA Coavoy-Sanchez, LA da Costa Marques… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: Nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) are, to
date, the identified members of the gasotransmitter family, which consists of gaseous …

Is nitric oxide overproduction the target of choice for the management of septic shock?

F Feihl, B Waeber, L Liaudet - Pharmacology & therapeutics, 2001 - Elsevier
Sepsis is a heterogeneous class of syndromes caused by a systemic inflammatory response
to infection. Septic shock, a severe form of sepsis, is associated with the development of …