Highlights•Psychological stress can dysregulate the human immune system.•Stress can
impact immunity differentially across individuals and contexts.•Recent work in this area has …

Research over the past three to four decades has clearly established that psychological
stress affects clinically relevant immune system outcomes, including inflammatory …

In the past 40 years, a growing body of literature has shown that chronic psychological
stress can lead to immune dysregulation. Notably, these stress-induced immune changes …

Although the concept of stress has earned a bad reputation, it is important to recognize that
the adaptive purpose of a physiological stress response is to promote survival during fight or …

Psychoneuroimmunology (PNI) research has long been concerned with the relationships
between excessive psychological stress and health risks. Ancient medical authorities …

A competent immune response is central to good health. There is good evidence that both
aging and psychological stress can dysregulate immune function, resulting in changes in …

There is considerable evidence that stressful early life events influence a variety of physical
health problems later in life. Childhood adversity has been linked to elevated rates of …

It is widely believed that stress suppresses immune function and increases susceptibility to
infections and cancer. Paradoxically, stress is also known to exacerbate allergic …

This article presents a meta-analysis of the literature on stress and immunity in humans. The
primary analyses include all relevant studies irrespective of the measure or manipulation of …

The communication between the central nervous system and the immune system occurs via
a complex network of bidirectional signals linking the nervous, endocrine and immune …