Oxymatrine: a current overview of its health benefits

DQ Huan, NQ Hop, NT Son - Fitoterapia, 2023 - Elsevier
Oxymatrine (OMT), was identified as a quinolizidine alkaloid, which was one of the major
matrine-type alkaloids extracted from Sophora medicinal plants. Growing studies revealed …

Anti-tumor activities of matrine and oxymatrine: literature review

Y Liu, Y Xu, W Ji, X Li, B Sun, Q Gao, C Su - Tumor Biology, 2014 - Springer
Matrine (MT) and oxymatrine (OMT), two kinds of alkaloid components found in the roots of
Sophora species, have various pharmacological activities and are demonstrated to have …

Gastroprotective and anti‐ulcer effects of oxymatrine against several gastric ulcer models in rats: Possible roles of antioxidant, antiinflammatory, and prosurvival …

Y Fu, H Wu, H Cui, Y Li, C Li - Phytotherapy Research, 2018 - Wiley Online Library
Oxymatrine (OXY) has antioxidative and antiinflammatory activities. In the present work, we
investigate the effects of OXY on gastric ulcer models and elucidate the underlying …

RETRACTED: Effects of oxymatrine on the proliferation and apoptosis of human hepatoma carcinoma cells

Y Liu, T Bi, W Dai, G Wang, L Qian, Q Gao, G Shen - 2016 - journals.sagepub.com
Oxymatrine, one of the main active components of extracts from the dry roots of Sophora
flavescens, has been reported to possess anticancer activities in vitro and in vivo. However …

Anti-cancer effects of oxymatrine are mediated through multiple molecular mechanism (s) in tumor models

CE Halim, SL Xinjing, L Fan, JB Vitarbo, F Arfuso… - Pharmacological …, 2019 - Elsevier
Oxymatrine (OMT) is a quinolizidine alkaloid derived from the roots of the Sophora genus
plants. It has been widely used as a treatment for chronic hepatitis infections and …

Oxymatrine protects against l-arginine-induced acute pancreatitis and intestine injury involving Th1/Th17 cytokines and MAPK/NF-κB signalling

Z Zhang, Q Liu, H Zang, Q Shao, T Sun - Pharmaceutical biology, 2019 - Taylor & Francis
Context: Oxymatrine (OMT) has various pharmacological effects, including immune reaction
regulation, anti-inflammation and anti-hypersensitive reaction. Objective: This is the first …

Oxymatrine exerts organ-and tissue-protective effects by regulating inflammation, oxidative stress, apoptosis, and fibrosis: from bench to bedside

X Lan, J Zhao, Y Zhang, Y Chen, Y Liu, F Xu - Pharmacological research, 2020 - Elsevier
Oxymatrine is a quinazine alkaloid extracted from Sophora flavescens with various
therapeutic effects such as organ-and tissue-protective, anti-inflammatory, anti-cancer, and …

Pharmacokinetic characterization of oxymatrine and matrine in rats after oral administration of radix Sophorae tonkinensis extract and oxymatrine by sensitive and …

L Tang, LN Dong, XJ Peng, Y Li, J Shi, FY Zhou… - … of pharmaceutical and …, 2013 - Elsevier
The purpose of this study is to systematically investigate the pharmacokinetic (PK) behaviors
of radix Sophorae tonkinensis (S. tonkinensis) using oxymatrine (OMT) and matrine (MT) as …

[HTML][HTML] Oxymatrine inhibits the proliferation of prostate cancer cells in vitro and in vivo

C Wu, W Huang, Y Guo, P Xia… - Molecular …, 2015 - spandidos-publications.com
Oxymatrine is an alkaloid, which is derived from the traditional Chinese herb, Sophora
flavescens Aiton. Oxymatrine has been shown to exhibit anti‑inflammatory, antiviral, and …

Oxymatrine synergistically enhances antitumor activity of oxaliplatin in colon carcinoma through PI3K/AKT/mTOR pathway

Y Liu, T Bi, Z Wang, G Wu, L Qian, Q Gao, G Shen - Apoptosis, 2016 - Springer
Oxymatrine (OMT), one of the main active components of extracts from the dry roots of
Sophora flavescens, has been reported to possess many pharmacological properties …