The treatment of sepsis and septic shock remains a clinical conundrum, and recent
prospective trials with biological response modifiers aimed at the inflammatory response …

Sepsis is the leading cause of death in surgical intensive care units and is a major cause of
morbidity and mortality in neonatal and medical intensive care units. The Centers for …

Although the prevailing concept has been that mortality in sepsis results from an unbridled
hyper-inflammatory cytokine-mediated response, the failure of more than 30 clinical trials to …

Sepsis induces extensive lymphocyte apoptosis, a process which may be beneficial to host
survival by down-regulating the inflammatory response or, alternatively, harmful by impairing …

Recent research has yielded many interesting and potentially important therapeutic targets
in sepsis. Specifically, the effects of antagonistic anti-cytokine therapies (tumor necrosis …

Sepsis is an important clinical problem with a mortality rate of 20% to 30%. Lymphocyte
apoptosis has been recognized as an important step in the pathogenesis of experimental …

Sepsis, a widely prevalent disease with increasing morbidity and mortality, is thought to
result from uncontrolled inflammatory responses to microbial infection and/or components …

Sepsis demonstrates a marked dysregulation of the immune system in its ability to fight
infection. Previous models have focused on the mechanisms which upregulate and sustain …

The inability of present therapies to mitigate the devastating effects of sepsis and multiple
organ failure in the critically ill patient indicates that more knowledge of the pathophysiology …

Sepsis is the leading cause of morbidity and mortality in critically ill patients in many
intensive care units. The pathophysiology of organ failure and death in patients with sepsis …