Expression, purification, and characterisation of the p53 binding domain of Retinoblastoma binding protein 6 (RBBP6)
BL Russell, M Ntwasa - Plos one, 2023 - journals.plos.org
RBBP6 is a 250 kDa eukaryotic protein known to be a negative regulator of p53 and
essential for embryonic development. Furthermore, RBBP6 is a critical element in …
essential for embryonic development. Furthermore, RBBP6 is a critical element in …
[PDF][PDF] The retinoblastoma binding protein 6 family is essential for embryonic development and carcinogenesis
Regulators of the tumour suppressor protein, p53 are promising anti-cancer drug
candidates. The retinoblastoma binding protein 6 (RBBP6), a p53 negative regulator, has …
candidates. The retinoblastoma binding protein 6 (RBBP6), a p53 negative regulator, has …
Expression and function of retinoblastoma binding protein 6 (RBBP6) in human lung cancer
LR Motadi, KD Bhoola, Z Dlamini - Immunobiology, 2011 - Elsevier
Retinoblastoma binding protein 6 (RBBP6) interacts with both p53 and pRb, and has been
identified as an E3 ubiquitin ligase due to the presence of a RING finger domain. RBBP6 …
identified as an E3 ubiquitin ligase due to the presence of a RING finger domain. RBBP6 …
Expression Analysis of RbBP6 in human cancers: a Prospective biomarker
Abstract Retinoblastoma binding protein 6 (RBBP6) is a cancer-related protein that has
been implicated in the regulation of cell cycle and apoptosis. RBBP6 isoform 1 has been …
been implicated in the regulation of cell cycle and apoptosis. RBBP6 isoform 1 has been …
[PDF][PDF] Implications of RBBP6 in various types of cancer.
Background: The 2 50 k Da r etinoblastoma bi nding pr otein 6 (RBBP6) was cloned over a
decade ago and was found to bind both the p53 and Rb1 tumor suppressor proteins. In …
decade ago and was found to bind both the p53 and Rb1 tumor suppressor proteins. In …
[PDF][PDF] The retinoblastoma binding protein 6 is a potential target for therapeutic drugs
M Ntwasa - Biotechnol. Mol. Biol. Rev, 2008 - academia.edu
The retinoblastoma binding protein 6 (RBBP6) proteins (also called P-53 Associated Cell
Testis Derived (PACT)) are highly upregulated in esophageal cancer and enhance the …
Testis Derived (PACT)) are highly upregulated in esophageal cancer and enhance the …
Retinoblastoma binding protein 6, another p53 monitor
M Ntwasa - Trends in cancer, 2016 - cell.com
The retinoblastoma binding protein 6 (RBBP6), a p53 negative regulator, is essential for
embryonic development. Its loss-of-function phenotype is similar to mouse double minute …
embryonic development. Its loss-of-function phenotype is similar to mouse double minute …
Overexpression of RBBP6, alone or combined with mutant TP53, is predictive of poor prognosis in colon cancer
J Chen, H Tang, Z Wu, C Zhou, T Jiang, Y Xue… - PloS one, 2013 - journals.plos.org
Retinoblastoma binding protein 6 (RBBP6) plays an important role in chaperone-mediated
ubiquitination and interacts with TP53 in carcinogenesis. However, the clinicopathologic …
ubiquitination and interacts with TP53 in carcinogenesis. However, the clinicopathologic …
[PDF][PDF] Functional analysis and characterization of the human RBBP6 promoters based on a combination of molecular biology and in silico approaches provide …
Retinoblastoma Binding Protein 6 (RBBP6) has been implicated in the apoptotic pathway
and regulation of the cell cycle through its interaction with p53, Rb and YB1 and …
and regulation of the cell cycle through its interaction with p53, Rb and YB1 and …
Expression studies of RBBP6 in breast and cervical cancer suggests a role in apoptosis activation
Ubiquitin-like DWNN domain and RING finger-like domain presence on Retinoblastoma
Binding protein 6 (RBBP6), is linked to its function as cancer promoting gene through p53 …
Binding protein 6 (RBBP6), is linked to its function as cancer promoting gene through p53 …