Studies of naturally occurring mutations of the RB1 tumor suppressor gene have indicated
that the E1A/T antigen-binding domain is important for pRb function. Mutations engineered …

Loss of a functional retinoblastoma tumor suppressor gene product, pRB, is a key step in the
development of many human tumors. pRB is a negative regulator of cell proliferation and …

The retinoblastoma (RB) tumour suppressor protein is capable of repressing the activity of
promoters containing DNA binding sites for the transcription factor E2F. Recently a protein …

Much has been written about the functions of the E2F transcription factor and the product of
the retinoblastoma tumor suppressor gene (pRB). These proteins have been described in …

The activity of the E2F transcription factor is controlled by physical association with the
retinoblastoma protein (pRB) and two related proteins, p107 and p130. The pRB family …

The retinoblastoma protein (pFl6) plays an important role in the control of cell proliferation,
apparently by binding to and regulating cellular transcription factors such as E2F. Here we …

An intact T/E1A-binding domain (the pocket) is necessary, but not sufficient, for the
retinoblastoma protein (RB) to bind to DNA-protein complexes containing E2F and for RB to …

The product of the retinoblastoma tumor suppressor gene interacts with the transcription
factor E2F. Two distinct types of interactions can be detected between the retinoblastoma …

Recent experiments in understanding the mechanism of the retinoblastoma protein (RB)
function have revealed the existence of several cellular proteins that are complexed with RB …

The retinoblastoma gene product (pRB) is a known tumor suppressor, capable of arresting
growth in mid-to-late G1. Part of its growth suppression action arises from interaction (s) with …