Exon 5 Polymorphisms in the O6-Alkylguanine DNA Alkyltransferase Gene and Lung Cancer Risk in Non–Smokers Exposed to Second-Hand Smoke
Purpose: The objective of the study was to examine the association of three exon 5 variants
in the O 6-alkylguanine DNA alkyltransferase (AGT) gene involved in the repair of the …
in the O 6-alkylguanine DNA alkyltransferase (AGT) gene involved in the repair of the …
Role of Polymorphisms in Codons 143 and 160 of the O6-Alkylguanine DNA Alkyltransferase Gene in Lung Cancer Risk
TB Kaur, JM Travaline, JP Gaughan, JP Richie Jr… - … Biomarkers & Prevention, 2000 - AACR
Abstract O 6-Alkylguanine DNA alkyltransferase (AGT) plays an important role in the repair
of alkylating agent-induced DNA damage and protection from the carcinogenic effects of …
of alkylating agent-induced DNA damage and protection from the carcinogenic effects of …
O6‐alkylguanine‐DNA alkyltransferase gene polymorphisms and the risk of primary lung cancer
Abstract O6‐alkylguanine‐DNA alkyltransferase (AGT) plays an important role in the repair
of O6‐alkylguanine adducts, which are major mutagenic lesions produced by environmental …
of O6‐alkylguanine adducts, which are major mutagenic lesions produced by environmental …
Association between lung cancer risk and single nucleotide polymorphisms in the first intron and codon 178 of the DNA repair gene, O6‐alkylguanine–DNA …
PAJ Crosbie, G McGown, MR Thorncroft… - … journal of cancer, 2008 - Wiley Online Library
The association between lung cancer risk and 2 polymorphisms, rs12268840 and
rs2308327 (codon K178R), in the DNA repair protein, O6‐alkylguanine–DNA …
rs2308327 (codon K178R), in the DNA repair protein, O6‐alkylguanine–DNA …
Associations between smoking, GST genotypes and N7-methylguanine levels in DNA extracted from bronchial lavage cells
N7-Methylguanine (N7-MeG) DNA adducts are markers of human exposure to methylating
agents including tobacco-specific nitrosamines (TSNAs). Repair of this adduct is poor, so …
agents including tobacco-specific nitrosamines (TSNAs). Repair of this adduct is poor, so …
DNA Sequence Context Affects Repair of the Tobacco-Specific Adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by Human O6-Alkylguanine-DNA Alkyltransferases
RS Mijal, S Kanugula, CC Vu, Q Fang, AE Pegg… - Cancer research, 2006 - AACR
The repair protein O 6-alkylguanine-DNA alkyltransferase (AGT) protects cells from the
mutagenic and carcinogenic effects of alkylating agents by removing O 6-alkylguanine …
mutagenic and carcinogenic effects of alkylating agents by removing O 6-alkylguanine …
CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers: a pooled analysis
Polymorphisms for genes encoding the metabolic enzymes cytochrome P450 1A1
(CYP1A1) and glutathione S-transferase M1 (GSTM1) might contribute to the variability in …
(CYP1A1) and glutathione S-transferase M1 (GSTM1) might contribute to the variability in …
Associations between carcinogen–DNA damage, glutathione S-transferase genotypes, and risk of lung cancer in the prospective Physicians' Health Cohort Study
FP Perera, LVA Mooney, M Stampfer… - …, 2002 - academic.oup.com
DNA damage from polycyclic aromatic hydrocarbons (PAH) and other aromatic/hydrophobic
compounds has been implicated in case–control studies as a risk factor for lung cancer, as …
compounds has been implicated in case–control studies as a risk factor for lung cancer, as …
Genetic polymorphisms in CYP1B1, GSTA1, NQO1 and NAT2 and the risk of lung cancer
M Sørensen, H Autrup, A Tjønneland, K Overvad… - Cancer Letters, 2005 - Elsevier
In a population-based case-cohort study, we have investigated the occurrence of lung
cancer in relation to polymorphisms in the phase I gene cytochrome P450 1B1 and in the …
cancer in relation to polymorphisms in the phase I gene cytochrome P450 1B1 and in the …
Lung Cancer Risk in Nonsmokers and GSTM1 and GSTT1 Genetic Polymorphism
Glutathione S-transferase (GST) polymorphism may contribute to the individual variability in
detoxifying lung carcinogens. This effect might be particularly relevant at low-level exposure …
detoxifying lung carcinogens. This effect might be particularly relevant at low-level exposure …